t T L Y P, P lanuary rch 3@l ;a v La to r a to r,/ of k L Y 1 T @,A L NT* o-F acte -aere encounter%-.d- durtn,o thts. qu,-,rfcr, I-landling of payroll and payr.,cnf of vouc,icr!; by the t-,L3tional lactitu,.-c or, iN4e i3 i a'i-ltza'ltlr'i is loa fuic'Tlorll-,io onally, -.itnor errors have bccn co=tfted bec .ous- -th (@c C,3 -S of fet-en-.c2.-. bett-cerl @bspi-tal Division and Nl.!,'ci pra--tlc.,.S, but as t I r,-.c goes on these crrors ihould be ell-31nated, Clinical stud'ies durtno t'*-ie quarter v.,cre larcely concerned vitih continuing searcli for codc2tnc-subsfltuile$, th-- ad-Jtcfion Inc m$'-.turc.%j, infoxic-ifton wtilh of, lvsergtc acid, and @1144h 'k. c cttr.icel endocrinotoe,,y of'addictiort.'. I2t: n,,-w appcars 't-r@at the addl--tion fiabifly..ty of L-@-1-il r o x r a n a ey,--ccJ fliat cannot be rcCarJed as 3afc ccc!.AIne .'eu@Wsilllufcs. I h a bccn sho@iipi a r..Ixtur-, for eac%, can be used T-or period-- c-,' 30 day;p Q a r y r-s ic, '-t;s i f r2 dc i @-,z d I ii o @'nrn: it lo.-i z; i f s --,c ve rc c ra i n s Ilu eC!A i cS. vcs accor.-,oiishcd wiih rcrpeci 110 fliz a n the ac I tV of t!ic 7-,ut u I f-- ra n,-4 r c n a 2- n-s )ro.jccf s -arc bci,o carried cut in collal-or,,tio @it iii attier -forics FounJaflop. for @@-xpcrlr;tcntat Siolo0y.. ?.!W-ss a nc.1 2 ln-.-titute,- octli'Csda a r I/ z; i (I' resul f s are no v@. t a va I 1,,b le The 'ncuro;)Nysiolo-Ical rection has 'norr zuecacded In ph,/sical dependenea on 2 li dogs. This scei-ion lia,2 aI-Jo bcen aftemptlno to co@-iptctcly :,ircvent -mrph depress %@oti in dogs by of very faroc 131-iDunt.. of t-,Iallln2e a,#,, Infervals of t,%ree hours. It ts hopcd that this cx,,)crt;r.,-ni vilit constitu,tc a tcst bf the "adaptation" hypothcsts oT' 'The dzveloo@@ne.-!f c 2 n L, n c c I s b i'5 I The r-@svtiz -to -4t"'a r cnce &nd r,@-fute Val. act !on,' thc-nrvo Co Dipl.,.asfc Acfton rith Cos'cs of 75 produ.--c Art,-r 6 in tile hirdlir-b reflex of chronic spinal rev-rsal occut-s ands In addiction., tistrychni2ne-like" cf"r'ccllz -pc r These rese-ible In every rc:pzct 'he bv -irril.-abl!4144Y scen clvrinc. chronic acl,=InfziLration of mcpcrl-Jitic In s-.nallcr doscs. a Addictio do '.-,t,,pcrldiri n In D-ags. We or-. -tiow ible fr, consts@cntty precipffate abstlncnec from 2 la doos tha'T WC*MC rccct--.,Iao r.-,epcrldlnc chronlcatty.- This he.-P.beca @ips4lbic by admintstcrtn,g r.,.cp-ridine ev.-ry thr:e houri@----' 2 r..,e eoscs @.10 tha w,@lzh These thal*- the %,sar, ar-- rpan* 2 a.,:. *,I I j@, ri, ri r a t v z c s c ,n c r I d I n o c r, s f I c .5 t I n o f a I I I r. c u n m- I n a f c c i c f b I n d- b r c a z P-- i7, ,3cr Id annual r C c a a -,:!,n I d d sz n t e, i- r C r! c@! C C, s z Pi@ 016) of v;ss rap;'dly lncreisz-.1 from to 12 C"J- r-,jAg. of t-,'aII4*nc prcclpif- 2 addiflonal eoc"sj, eo-#ase O' w,3s I.,icreased to 17 h da% Is 2 pr!zclpltal-ej In f.Yplcal abstin-,rc.e, The$,- rasults fndicafe fhat if is vcry likety that a shcrt., tcst., @,,Ihlch could be us--d by 2 hOuSCS for d-pc,.i,,4cnce flobility c@' 'ICU an cslcs, can be developed. Go 51"Udics c;n b SIPS 01-twzcn C@,-rdif 2 a,,id C-1-itlnction oT' Alpha B.., o 4nd E.-c ta. f@ T has re,-3-ff -,? fhat fo cor4,;c3i I r. i@ I b I o,-i . T,@Q- theory al@.4vanct.-ct' L,,/ j-' rs invesf 1:; '-as-d 0.1 f 1 U- f i. e. b i o c r@ 1'1-z E7@ G %,ja s c,: 1 @),47 1 s,2'-. f ti%cs beca..--e n, r r C t Ir-c d-f vz:rlabl@ze- -b I o a b lo,"@ ard Y,)Iun2itary hand r s -on,; s a n Z o u S 1 @a t a S C: @s ,-I r o @O V. ',I a a P i'i ;a 'C Iu C a t i 2 y@D I vz d s feci@ "I 'tc @y r c r a L-, d i:,-, I I -,Ii o t C k I c: u a -4@ ,I,& Z r C S o@ C casc--t a low folic T,% 13 - P. es u I I;i I -a blcckae-- 1 o, ii "t) r c r; n,@l loii de As t r. f r@ u I s w,@ I h rcsponsc a,,id @os su,.-h U&@4-iinot be.coii@4l@ e c Induces fhc alpha bicckade 13 cont-I nucd, bfockl-- 'r o " a p@-a 2,-radva I 1 y d t,,, - pz.,, rs .- Til s 1!3 i r uct ro-ear-.Ilc:ss of tiie ntifure c,f t@,e sil riulus .ap llght or sound Induces t'nz sori@z effecls. IT' the stimulus 2 Is dis- conilnucdx.alpho bloc.',,-.Ing rca:) .pears when th- stl;-.ulus Is roini-roducedp only to a,,-ain 3lowly disappcaro 2* Experl,-@-,en@at Psycholoo@y 2 Hospital .?r6ject '.valuatlon of P.-ycliot@cr,3py. The psyctioioof,,t was it loarsed" to the clliilcal dlvlzl,on of thz hosittal fo assist in for.-iul@afts-ig plans for evaiua$4!ot-) of effecfs of ,)sychofhcrapy on tis'c reia.,-,sc ra-tl.-- In c n d o n c -ii a I f r,-. -o -i Iii f f 'ii ci, s n t I ti t s Th-, prcllnlnary pill-,f study wh,,?-,h It bzln,@7, carr;ad out by clintcal d 1 v I s I o n p c r s o p a - i d t c h I s d; 1 - n I amcntb!U- In all adriil#ssionz Is Currantly bo !.;;;nnesota c Pei-,soio I 't v I n vc.-i toi, I c- i of -,e,,Icfs. T,lc -&:n-ii'z of 2 pllysician aciiitets liar, be,@.-ii slar@ed fi%e c4-' fl@c ..3,-Illty T,-c ro i:,, aiti,u, j avlii a a r s v 0 p r c s ---,ri i a ui i,,i!j a c-- 0 r -,-i I.o ror ph,/SictZD4-P in --nZralp fhe aftt-U0-- tot.7-ar,-4 a.,i i s c -- 1 @2 1 b c,', a 11-3 r I -p@ n c i I n 5 a z 0 c C, C, sucn L-:',,iaviore @i i @'i c o f 'ii a -i d i@ c the physicians 'c 'vz PRO.T cs. rJh I ch are sir,,f I a r jo thosc of the avzragz cddic'r In the hozi@,ifal Popu'0+101-1,, If r-11:3h@ be Inf,@.,rrcd fhz @ Pcr- sonality characo4crisozics ar., Of.addictlan tlia@n are the availabilif,/ of dru-Cs or special rroup To date, 13 propli@ 2-S.@-avz b,,>cn obtained ol physiclan addictso As Pdticr,.ts b pcrr-ilt s ;in if t'czsnf C or"parison viffh th-- hocpitat Dropulatlton i-iii.1 f2ie bulsff U.;O Ps ycho lo:o Ca Dai4 During ronic Alcoholic Infoxi-, caf !on, T%e du't,:: GI,-if a I nL>,d dur fha chronic oilcot%olic 1,-)loxlcatio T 2 stucly lie$ bc n fully analyz.-cl. The rc-,o,-kt concer ce, ..r,zd all cli-itcal scaics durino chrgnic intoxi,.Of Ion s ,rc ti o C,%.@ D 0 To e-ate tt)c ms,- s i,n if je. In 'his si@udy hav, b^en P, no n y o c 0 c s . z n patic, c t,,r re bz I 2 r,g t--sfed. ry too @(S IC 3 A-na r - i n,3 C.,, i t,^Lfnrler C. used' @c.- S of! r s r,,,fz. Tit@? rc,.@a2ilno dizc t,,-pe; ffic ->rcssurc r.-qu 1 rl;-d fo -t+e sa 14- C bwh --:.I b I e- ri -1 I @-, - C d b s ubs i 1 i u a e C v C) for the r@.,zchanlca) cor-:@it aci- ri v o @p < IU to 2 -3 lu C (,I t7i t4 4u lo 2 t2 44 ki C: ea 03 1.) i,,) 40 Z) E:- t 0 fit t4 !t4 14 t E- 'o t-- C r -Z C U r C- C a C,' 1-;Izdlcal Dirccfor @forrol.-, "C I T;i 14 Cal Janu,ai 270 1954. Ics of Drt!- 2 1-@-'.cd I c.5 I arid @ @-,r s 1a St. soob i-',o Laxingilons l@y. Fcbrua.-y 2, 1954. a rd of Elru.- 2 Unlycrst@tly oT' Cir4cl,-tna&li C-01!c-c o'j' Lc iu' C I I,. 7z Cl nc I i'@h Io.. t' "@3 r C !I 4,o "Chronic Alco.@ollc of o2f C'Snciiinat"l I-,-; I I C O," CinCin,-,af 1,. U.-; I c@ r Coil cri- o' ,@cdizlpc Cl-cli-.iall .0 @ia r c;i S C ."irch Frascv-t' C,@ r o r, I c r, ,-,c Ica f icvi n C r b I I 2 1 v-r, I t-'a .3 I- i-A C s,-rics of 11 r all" n f:lZ 3r, I'n VP A!?a D, r 1,,, t - to r, s. a,, d C !@l.-asurer:i.3ni, cf P u r o c a u,-, c 2 Ions "Pain and Anal-c.,Ii pscylr ,CO I ve i@ 5 n o r y s D 1 Tt! s la I e,!' i c?rO] c@ c 9-11 oand Rcf lcutor A--f i'v'.gf ln,.-y In ,-,O--clousress o@T' Al-losorjnos la, of SC'-cf' 2 a n 'in Coisclou n,!s 0 2 a-c o c c @o,-; I 4,-, cl L c,- rn I ng i-)f n@-:0 r,, c-, 2 41 i@ Ut- - of ii I- I n v a u,.ri 'il A n a I -,z s I cu - A!:@ s f I'* In tia:n r,,--ta co I I 5 4 9 t' A. -,-rc! L o,;., c r r c c r, a n d r c -z@- c c a r 4;, J i 934 to r Isbell.- 9 August Inviied fo n--rttclpc$4-@ In Sy-@poslun on I c 0, i o 1,i d I c c '-s -@D s -.-;i 5 lo I r. t e ticva, Ctrtci;%.nati. C-en--ral Ho s -.:> I i a Ii 0 i d I o ;'c u r oo:g ii u@, o IIric a I ations of Dr u"-7 A ed IC f Ion. Vanderbl!f Univ.-rsikys Dl-.p@-. of Phirl-vacol.,, Nos T c n,,2, Cify oT' Defro'j'f, i'.Ii C,% so ot Boston# 'Vass$ 2 Dantal rienfvcky sc,,,ool o-@' llcd..$ livi I De,? ..tof s try, So u'thcr n Co 1 1 C, f r C -.7 d I a I CO I C:7 C of S,-Uth -Iro I III Den "r 0 i IC 11 - Sy Iia ii @@.3 vz i Inn. iiir. Sinai 2 Y* 3 Of @7, 1C- cr@,c o ;n -C ->f . c,@ C 0 1 Si-r I Ich Sc!,.oc,, I c-T' @z i vo,ia 4..;n r S @t- V 1 U @t, f I n C ct z Kefl@ etc!" IC$ Clir.,Icl cl,y o tin S Y o yo n 1 n - 0 1.@ C.1'.001 of Phari-zcolo!itt,, 2 L a r c 4,yo -I n Unfv;rsity of Ufz.,% Colicoc of Pherwacyt Safi 2 Cify, Ufah n f.e t,'illverslf,/ Collcoc 0-1@@ Pharc.,%-*cv, Brook!yn-, '-!.Y. DCpf. 2 o,@*@ P@SaIr,-iacolf-)cy,, Ui)tvzrst@-1,'of' liti.,10;3 Cc>IIQCe of t-"lcdlclne- '%-hlcaoo, Dept. of p'syclilotr,%).. 2 YorL- city" INI.Y. Co-f t@-c-.c of afc collc!oe" Po ci C C.@ S, 2 Loyol-3 U-,ifv-zr'sity, 1) c OF,!i, of P,'iarz-ac-o C a V.;@l, n r c.ti o a 1': c 1 T 2 C* r p a toil or /@bsilnt-.ncz Synd.-o=s bv !;z@c or' -Icdlca .1 L;v's ilun., @-oznpany,, r i:nc 4i i, a i c 2 Cc 1,--c Cr d L L of c, 4'..3 n 4 ,@Ic d I S T* C o o Dr. D,,-, a I II va- J<-rucrv 'Dr A I I D, Bass$ Vand!@-rtjl'l@ Unt-,",rsliy T..7r- - Jan uarv 2 ..41 Dr* C* H i r-4--le I s b a C as% I itr-, on i) 10C Dr. Vtcfor Vt. Voct., Paris# Pr-,r4ce D. r J. B. Kahn, Jr* (-Tntv--rsif,/ of Ctnc?nnaft Col! 2 WCC,@iz of Dr. Georoc H. Ac.5-son I f., arch Dr, Co na n go r n c s Lono lsl,),Id@lictonicat Assn, Long lstancl., @-I.Y. II-'-:! r cli I r;a' 4