WEt RE put,!ic -iont of HEALTH, EDUCATION. A@" T I 0 N A L I N S T I T U T E 0 i E: A 'L.T Fi' N I June 1955 tx itannots. ADONIS$ TWX Aoi)tcTlolt RESEARCH CE4TEP I$A=mAtimnlUnS Of MINTAL NKAI.IW U. S. ptIgUC MCALTM. lt"eg IHOSPITAL NR 1000 UninsTan. KtnTucnr was away from Lexins'ton last week so the preliminary description of' the C-9 could not be c2ompleted until my return. This has now been finished and Is attached to the original [.,etter. since writihgl'you on Iviay 2;')rd the work with Frenquel orally .as a blocker of LSD has been completed and table Giving the results is at4,ached. You will note that the differcnces b2etween placcbo-LSD and Frenguel-LSD are insignificant. It Is concluded that ln:the doeage used F,-o.,nquet is Ineffective in aiterine the LSD-reaction. I 'am., of course, sending these data on to th@Win. S. i'v@ierrell Company, who so.kindl,/ suppllzd .-,e with the.-drug. I am, als'o thinkirig of sendin2g a short rojc to Selence concerning these negative results. Tri' als of slnfhetic LSD are underway. Mild but defivi c LSD-like -cffects hav- been observed with this material in doses of 25 mc-M. Trials of larger doses should begin next week. Very sincerely yours, 4 Ha r r I sI s be I INI.D Di-rec@er of Research Hl:rn Attachment I EFF,ECTS OF F R EN@'")U t- L20 IVGV,. T. L*D.'ORALLY ON R-EACTION INDLJCED By 60 MCG. OF LSD N'TEASURE DRUG ;renquei Frgnquel Fre.-iquef-- Eren 2 quei -Placebo 4 4- LSD Placebo LSD Placebo. Placebo 4. LSD LSD Knee Jtrk 4 1.24 4'0,S7 4 3.14 4- 3.28 Pupillary Size 4- 0.34 0.65 2 3,68 3.56 SYstolic Blood Pressure 0.63 4. 1.01 4- 2049 2.24 Nb. Pozi-'tive Answers C'n Questionnztre 9 7 76 692 Cli-nical Grade 4e 0 0 1.3