-rvi
                                                           -LFA@'   Pjblic u,,31,@ S
                               oF HEALTH, EDUCATION, AND
                                 NATIONAL I NSTITUTES OF                HEA.LTH
          IN RILPLYTKG AGONSSS T$49             24 August 1956
        HATICKAL INSTIrUTIt OF NTNTAL HGALTH
          AcoicTion RastA ex cgmrtn
        U.S. Pueuc NGALTR S:Rvica HosP4TAL                        t
             P. 0. Box too*
            LaxinGTON. Klmrucxr
                                                              @10)
                   O2n checking my files I find that we have some    Informa-
                   tion on oral administration of L-3-Hydroxy-N-pheneti'iyl-
                   morphinan..@ Data indicate that the effects of  the  drug
                   are erratic when  given  orally
                                                 _ Ias contrasted to being
                     ry consisten.t"irhe-r@--@'i@ten'-subQul-aneous;_y. I2t has been
                                                               mg
                     Ve-if-i-n" d-oses ranging betwie-n --0.5 i-6 (total)
                   to adult itale postaddicts.  Defi'Aite morphine-like effects
                 /'were obsetved in some Individuals at  every  dose  level.
                 @These ranged from extrent"e'ly mild to very Intense.  Onset
               2               -as also erratic, appearing from one  hour  to
                 )Of action w
                  @as long as twelve'.-
                   I fear this indicates that  the drug is erratically
                   absorbed.  This may have some connection with Its limite'd
                   solubility. Altl,.ough I  will check., I now feel that It Is
                   probably ndt as  promising  an agent as 1-dromoran.
                                     7           Very sincerely yours,
                                                Harris Isbell,  i'A. D.
                                                Director,
                 'Hl*.rn