19 Yay 67-A CPO'-ZS PSIATOOCni4li. Receitly '4t haa becii sho-.n. et P, Itbello 1950@) th-ot tryptemine (horeaf fler refc,-4-e2d to a! psilacybin), a corpound Isolated ct,.rtain snecies of m-asl@rooms (HoL-i.-.-=Lll et al 10,58b) w4ilch ae used ccre,-,.orlatly b%j c-Ican (1--@azscn and, '@iaszoa, 19':77). llas rzycbotomimet.',c properties very si.-,Ilar to tlba,,oze of LSD-2,5. .L4,le close res=bla,,-@e of t.ic pattarns of sy,=pto=s Induced BY L.'M and Dsllocybin tuggested that '4-hesa dr44Cs cauae a ptyc4%os2ia hyalolo-Ical z,,,--,clianl=* ,y somz cc=..on blo.--h@:..nical or p - u "Inc-- t-l@-.9 ef4ot.-@i3 of LSD dl-mlnlah rapidly the d.-ug Is glvcai daily (13bell et ni2a 19'6)t It was felt f4*,Ilat tho h@root.-hasia -iat the LSD and psllocyb'4n psyclioses t: -;a idertlcal could be tei-Fted Ly datermir4l'.,,ig If crosn-*-o*4era=a existed belweei the t= dria-zo 1,.i ot""Lc@*" v;ordsp ir the doe,,ree o,-,% tlic lr.d4ced by a'gl*ven dcisi ot psilocyb'Ln v,-,= 31gnlflcartly lcs3 1.,i a per3on made tolerant to LSD, crosa tolerancc wuld be said to exz'-.,t, and, con,,,crscly, 4&.-u4.z reactioq to a given dose of LSD u@,.culd reduced In a p,-rso.-,i tolerant to -t33llocybin. I-a c-@se, i@40 t&s L:nDiled that @.olcran%-,z to p3i'&ocybin v.,ould de,ielop. c addict3 v@io were Flve r.-ale for-mor oplat' serving for violation-cf the t;o S. narcotic la-j3 wluz-p_tcerad for the exporlr-,snts. ages varied P-,2, 2 y%-.are, All we.-a phi,@sic,@sl-ly healtlty a,-id none preser,'%,.cd mny C%?I%-,Aence of the -,ajor psychota-.. All had .-aceived '"S@Z-2' Gencrnl (--ondiolions. 'ihe s,-,bjects vm-re housed In a spccl&al ward dwtot@'d to cl-inical research. Temperailuress r-.spiratory rates ap-d blood p*-essurcs vmre ricasured th4-ea times daily aftat- Ll,.e pal.-Lents had rested qiletly In bed durlrg days In which sp-.cial mca3urments re no*,, being =adz,, -atlc.,,its u-zrc observcd s"zclally train,-d aidou witli long experlence !n. det--ctt.-.g drug-induced changes In behavior, T,'qc design of the is s-.i -a--ri-:zcd Ir2. Table to LSD and -r,,silocill@in v@ere olven In 30 c-0 o&O cherry 3-y'rup at 3 asm, v4i4%1.,% the pa-tient3 fasting, All doses riere calculatzd on a ba3ts. Control exper'l2inents wcre carried ot,.44.# usinl 1#5 llcga,.g of LSDV ll_:,fO of psilocybt,,,% ard a olaccbol bvform the firsaf.- period of chronic Intoxica",.Ion a-id aftcr period o6l placabo medlcalf,.Ion prior to tz%e se.-.o.-Ld per**od or Co.,ttrol taests i7ith LSD an%-14 psilocybii %ic.-a