C3) DEPARTNIENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE 19 October 19'00 Natiestl Institute of @Mental Health Ad4iction Research Center U.L Ptib2Ut Health Sesvice Hospital LcaijLgton, Xentucky In accordance with Ray's teleohone call of October 1.0th I have followina suoplies of the materials on hand,. Agroclavi-ne (V-A-18), 440 mg, Dihydroagroclavine (V-A-19), 450 mg, DL'iydroergokr'y,-tine (2V-A-20), 25 mg, 7- 9-Di=,ethyl-9-hydrox-j-4, 5, -Da, 6, 6a, 7, 8, 9-octahydroindolo p [4 3-fgj qu' 'line (V-A-21, or Lilly 23194), 315 mg, ino Elymoclavine (V-A.-22), 100 mg. v_ou may have anv or all of t@ese materials since, v7i2th the excect,,.on of V-A-21, I can aet additioral supplies from -Dr. T. Yui of Takeda, Japan. We hal.,e never slt-.udied V-A-20 here. It was sent, wit.@iout our requ--stlng it, in the hope we would test if for adrenergic blocking pr--oerties. Key reference on numbers V-A-18, 19, 21 and 22 is: Yui, T. and Take2o, Y.: Neurooharmacoloal'-cal studies on a new series of e--got alkaloids, Japanese Journal of Pharr,,iacol-ogy, .1-. 157-lel (Marc@@,) 1958. The only informa.@14.on I have on V-A-21 or Lilly 21-19,@ is in the form of thermofax sheets sent -re by Dr. Slater c@f Lh,-- Lilly Laboratories. 41 They indicate L8D-like effects in cats and rats, but in man this compound had potent hypnotic prooerties. Looking forward to se-eing you soon, Very sinc-..--ely, E-arr3-'S@' tsvell, M. D. 0 Director I-,-_i:bws