41 IF4 2 rl4 t-4 vi ti> V) Li 0) > 2 Sri P4 V) 9;4 2 c)).. -c4 C,) 2 44 Ad 2 r3 1 4" 5 0) L) to C".--&Y oui the !P. ad,-@","'Ltio-n to etaluallon o an.al-le--.Ics S'.It)=Ittad b7 the .^,n Pddictior, ari i@7arcctics of 2 ad,-:.',,"aaral'fundz tl-,e o ri-, LI -"n -i ek.1 co ars Lqa P-- n c, a,: i ha; b a e r, e n Lh 9 n 1 n e haz been Two 2 and @lt-pro:,,oxyphe,-.,e to bo lecs addlativo Llm.-i codaim ar4 '.-,cth a4-@e tiey ar-,% le.-IS =d more toide 2 lift 'Le."-Z th= the -,ear,-we h,-.,j-e mm=Amd re-.,7 d=r,,-O, thz,,Ve, and p., repulc-d t,,,N 2b,,@- Lliat effactive in ral"vi dlae +.a - s=lar druc, po I_lu ar@d t."m-*om b-oth have r,--:.-,ed for an 6 Cm iz mor-3 @--sely to - -av,,erLe tll,-.,'l to !:.7-1 .X4 il?-. Ln cea a n,.t:qer ty-ric4 tips,-trurn o! =or:. e-ll"L,!.e ax@-,l 1f.s -anal-ec@tc poterc7 ;,@-i is n.Irrost equal to ti, of 2 ..at zmo- r =rphi..ne adz@ii@-.ts only =d=r subj,---cL',,-a ar-.' eV,.-acts c,-.=rrc-d -oral of as as eC-0 ..ng orally o:- "4S3 mg 2 r-ag orly@ I/ ich -as ,-ctc-,,.it as in abruct o@-6t c!-w -,;p to az .-. Auc@h d-al-Y fOr t.--.-O =1',thz, nO2 --7m;tO'.zs o:'. aL,,@,,timence is much less ad-d-IcL4ve L.%an i3 elLnic.a2 L-idicates t;i=t t:m,,s =,a7 b,:@ az effecl;va as Ln relic-vtr.-g min. IZ th2is is L-.-,o, then t.%a a' and addicuvw,,ezs y.--t achle.-led. a--=' aetl c POten.7 .3 4ub s@0' le O2nl7 1.1 hf.--7-My acid Bt::che=ical ztu,,'I-" cn the r-a,-- o! -and fate 016 co-d:@-tllrle W-A- -re @u.-inu tl:e ye-ar. Cod.-eina- and It-.- n:%odu,-.ts we.,-.e lzoL-.to@--Al ad.--Anlztz-.tion and S;olLxaing of CodLL?,.e @.o =rza.Uie addlct-zo u- ,der c@x-4,-:Ltr,,-,raphy. r,@6'he -ro lee, i@-. 2 Mt quar;4,;.t-ati.-n It; to be carric-.4 aLt,, asLng a g--up-- to h@i-- r@ct yet od--. 6 +--ba e --4c=@ted ez t ro @ @--ct 3 t, C,f t@-a All@,-hou-7,h L,--.-,;_%at d@e-al of be-on ard ta,-: w;allzblc- f-ir all rnw.,Toc-os !or 13 use,:I. --tW have ro is as 2 coe-4p-ira. L"ar,.,on a-,id a-"e n- ri@* az, Is co,4.,-,Ine; Is and draej in?--I-tion. .'7o -ditcot.,er.-,-Ad I-rico-riDo=- te@3 al-I tli-B ,,ro;erL'-:i o' cozl--line. rumlier =.ore data 'is on the e.-.crLti-.J"i A-@@ =d of th2.ae 2 all I 'Tidy I'@1.2 @-.e -.-O@none to tost tlie cltni,-al .nacrloc ".@nd sulf;on:p, It 2-Dlmethy.L a r4 - b y I I - I.- 2 0 aid All th-z,,!@e bo,,e.,n -.@ecom m *Io r stltl by tli-,-a on '@la-c 6-0= 2 Co=cil. in a. n t a ro ct th-o e:-xr-@tio,,n of eodai.-.e and its a* c-c-@an as a gas c.@i==ztog--aph Is end l'ollov,@i'MV c-t,,udier, an the and f -ate o.f 2 'L"he m-et:-,odz uzc-d a.-@e l@-io eta-.td@. o.4 the Adrtiction a---, on anzi ard ha;%,e bez:-n,,n --reviou,.,,@ ,nro5ect wiiif--h sh:@uld L%a con.-,Ultc-d for The u.--ed a,-,--% al,-t!o ar;d Involve serp.@-ti,-Jn of the drig--, meta;--,CL'tes b'7 with var'4,ous 2 f ro m L-".=rities by pape r @=p'@lq), and by a end rea-etior@,s chro=t^-g-L-,-@ r;rly., Ev*.Iu=or. c4 the d-ata h,-.%s 'oeer. cw,,.P-are-d L0y,. .v.,)rit wM '-e out at the .'-I Addl.--tion azea.-ch, t7.,o p fL, di, C-: ti,,.-e 0,-. to bo a pool o.1 vvith stzict c L-:to th,- Co=,Iet-2 f='"2',Ities are alzo T@ 14 i-.3 i t,, o rw. i Ue c s. c u t u n d,.,,. t'-h e d Ie,-. to n '& T. a rS I e U Llre.:t-3r, A,,'@L'cL'on l@3 - in r-o-search on na,-cotic d.,-ug add!--tion an@4. has a-ii the vn',ll lf.,4e azeie4i@,@ t7 tro cc-,er e: r -c-d r, h y i a., H. -7, a z- e r a I Ab z h i '1: k'l!d e rb 0 t h o 1 2 waho:= '.=e done e,,dersive in ezi -r-rany a b@'-cche=-izt,, and rc-aearc:-@. e-o P. A specw war,.4. -.or t.@ie c=--.ha,.,t o.f 4@,Lo--te has bc-,Pn r.P-3.da aN-alla;@li.@D by th.-. h-az bc-e-im* 7@;tl@rnnLted co-It Tb,a e-z-d-.-Aa@,ed cosiz are ca t!28 adaz:,Ied sheet. The a=u:it ot I= the as tbat renueeted for f *.-=I yen.,- Zir0e&.or Attachi-,ent 12-28-60