FRELII"'II14AR.Y t@%C-IPOPT ON F,-"02 The material furnished was Rept in a.desiccator in a cool room until required. Appropriate doses were suspended in ristilled water an,' administered orally. Subects were i'orn-@er niorplt--s-ine addicts, manv of them exper2 ienced with LS:). @--ate r i a I was administered with the patients fasting at k"; a.'-n. The measurements included bodv temperature, recumbe.rt an,---; standinn pulse rate, r ecumbent and standing 11-ilood pressures, p@pillary size, and threshold for !4neeler'r,@-s. pat'lents we.-P, questioned once hourl-,,7 concerni2ng any subiective sensations they might have experienced, with particular emplias4.s being placed on illusions and 'ballucinations. One or two patients were tested at a time ancl tests were done at intervals of a week. The dose was increased in a stepvtise fashion beninning with 0.5 gram and increasina to 2.5 orams, With the larger doses, 1.5 to 4.5 grams, we have consistentl,,r observed pupillary dilatation and Inconsistently decrease In the threshold for 'kneeierlt and a slight increase in blood pressure. No untoward toxic effects have developed. -.22- Page 2 The subj>1ptctive sensat>2p-l>2pons reported to date have been disappointing>1p. T>2pt>2pfo patients who have >1pr>1pe>2p6>1pe>1pi>1pv>1pe>1pd 2 grams of the materials denied any s>2pt>2pib>2piective experiences of any sort, other t>2phan slight nastric discomfort after >2pinjestion of t>2phe dru>2pc>1p. T>2pL>2p6>2p->2pse patients receiving the 2>1p.>2pn>1p'>1p-gram dose reporte2d slight nervousness, irritability at noise and other minor changes (these natients are >2p'>2pt>2p2pt>1pive to >1p1 mc>2po>2pr>2pn>1p.Ag>1p. >1p0f LSD). No gross c>2phanges in overt behavior >2phave been observed. >2pOn>1pl>2py 4 grams of the material are still on >2phand>1p. >2p!>2p4e feel that vie should increase the dose even more than we have, and that also we should have some of the >2pcrude material. as a reference s1tandard-. 4 Februar>2pl>2pi >1p1>2p0>1p5>1p8