DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBUC HFALTH SERVICE 17 March. 1958 Nedessi lud=n of mental H*Wth A"iction Resgmh Center U.L ftblic Health $emce Hospial Lextagon, g2eatocky Ihave worked the dose of C-5 up to loo mg./70 l(g. of body weight without obtaining any appreciable subjective mental effects, or any ob-iective changes in behavior. Cardiovascular effects of the degree seen with C-9 also have not been apparent. The material has been given in alcoholic solution by mouth. It appears to me that this-is2 a relatively inert drug. Do you wish me to take the dose any higher, or to discontinue study rJO it? I have to be in Washington from March 27th through April 3rd and will have some free time on Monday, March 31st and on Tuesday April Ist. I could come down for a visit If you so de-sire. -I-will give you a call while In Washington. 1 Sincerely yours, rr Me De Director HI:tkh:lw @j