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                          DEPARTMENT OF HEALTH, EDUCATION,              AND WELFARE
                                               PUBLIC IIEALTH SERVICE
                                               24 February 1958
      Nademal Institute of Mental Health
        Addktloa Resemb Center
      U.S. Public Reabb SoMes Hospital
          Lazing&*&, Kmtttcky
                   Do-you  have  any  infor:,nat;.oz, on the stal:.ililt,-,7 of C-5?
                   lire
                      have  been :naltin- a   solution of   this !-aL-.erial in
                   95-per  cent  alcohol in a    coiicentration o,    I
                   The solution is or2iginally light-bi-o@vn in        color., but
                   after a daar or two it becomes blue;.sh, as        if it ccntala,>,d
                   rr.ethylene blue.  Currently we are preparir,.o the solution
                   fresh on the @.iorning it is to be used.
                   We have now given as .nuch as 3 -Ig of            per 79 kg. of
                   body weight without oloserving any definite sutjeci'.Ive
                   effects.  There is a suggestioii (subject to proper
                   controls) that the following may be occurriiia:  drop in
                   diastolic blood pressure, in-.rcase in pulse rate, and
                   elevation in body te..nperature.   It is already apnarent
                   that C-5 orally will be far less pot.ent than C-9.
           2        I have not yet received the additional supPlY 0          f ',@-302,
                   or of the crude material.
                                                Yours very sincerely,
                                                Harris Isbell, @-I.D.
                                                Director
                   F,I:rn