7>1p' Dr, Bar---is lobe" Director of >2pPasearch U>1p.S>2p->2p. Public Health Ser>1pv>2pt>2pce >2pHos>2pp>2pital A>2pdd>2p:>2pL>2pct>2pi= Research Center Box 2>2pC>2p,>1p00 Lex>2p:>2pLngt>2po>2pn>2pj>2p, Kentucky Dear Dr. Isbell.* Your letter of 28 October 1958 was m2>2po>2pst >1pia>1pm>1p-mat>2p:>2pLve>2p-a>2pnd is greatly a_>2pn>2pp>2pm>2pc>2piated>1p. The obse>1prvati>2po>2pns cm the sedative>1p.effect of >2pc>2pom>2ppound >2pI>2pl>2po>1p. 23194 as well as your >2pc>2po>2p=e>1pats >2po>2pn Dr* Janssen's c>2pompound are most interesti>2png>1p. Both materials may >2pve>2pl>2p3>2p. prove to be of considerable >2pva>2p'>2p33>2pa >2pt>2pm our research end>2peavors>1p. 2 T>2phe the>2p=o>1pfax copy of Dr. >2pRof>2pt>2p@>2p.>2p-an>2p's presentati>2po>2pn on >2pP>1ps>1pi>1pl>2po>2pc>2p7>1pb>1pi>1pn is e >2pZ>1preatfu>2p->2pUy rec>2p'ived and provides us with >2p=>2pc>2ph >2pneed>2pod background >2pi>2pn>2pformatio>2pn>1p. I have read vith a Cr>2peat deal of Interest y>2pour a>2pn>2pn>2pu>2pa>2pl progress report c>2pa the addiction l>2piabilities of synthetic substitu2tes for c>2padine>1p. With refere>2pn>2pce to the previous mentioned c>2p=>2p.>2pDound of Dr. Janssen I >2p->2p,>2pj>2pc>2pu>2pl>1pd >2pa>2pl>2pm_reciate be>1pi>2pl>2pmg kept i>2pn>2pf>2po>1pr>2p=>2pd should the >2pc>2pompound or reports >2po>2pn its experimental use become ava>2pi>2plable>1p. I am pla>2p=>1ping to visit >2py>2po>2pu in January at a t>1pi>2p= a>1pc>2pc>2peptable to you. If you have>1p-a>2pn>2py sugge1sti>2poas as to >2pda>2pt>2pes acceptable to you please advise me. With k>2pi>1pr>2pa st personal regards,,