..TWX CODE NO@ DEPARTMENT OF LEX KY 47,7t LTH- EDUCATIO@L, AND W, ELFAR-= H r-A PUBLIC'.HF-ALTH SERVICE .LEXINGTON. KENTUCKY 230@Ap I 1 1953 PUBLic HEALTM SERVICE HOSPIT,%L NINI-4 Addiction Research Center As part of our researcb program for-.the coming ftscal year (July 19S3-juty 19S4) we are plan-niog to conduct a study of the mental and other pharmacological effects produced by the chronic administration of the d2iethyl-amide of lyserglc acid. We woq-ld aopreclafe any Information you have concern- Ing thts com@ound, as well as any advice and suggestions concerning. the propose-d work,,. We are particularly Interested In finding where we inight.o@tain a reasonably large quantify 2 of the drug. We also hope to ihve@stigafe the acut-c and chronic effects of a.number of derivatives of.-N-allylnorc-.orohlne In man. We are particularly Interested-l-n the levo isomer of 3-,%ydroxy- r4-altylmor;:5hTnen and the 3-methyl ether of N-altylmorphtnan. 2 Another, compound which may be of Interest to us Is N-propyl- d th ydremorph I ne. Finally, we hope to Investigate the effects of diet and of constituent's of food on blood alcohol disappearance curvei. I"would appreciate your advice concerntng the best methods of deteeminino blood alcohol. Very sincere'ly yourt,'. Harr-i sIsbell,, M.Do Director of Research Hi:rn Declass'-If le4 Ff &4F4 3 @'475.@.- dalts --- 4 LB 1977