14ay 25, 1966 Dcar Dr. Thank you for forwardinr, the two 13.-elininarY CO'3ies of your proposa" to me for review. I have taken the liberty of distributing copies to many of the interested Dersons fo,: information and comment. I will Iceep you.in- form2ed of all reactions as I receive the=. In the meantime, I have com- pleted my revie-vi and would like to take this ol,)po%Lunity to t.iaul,-. you for the effort -ou have ei-.vended in prepa.-4.nS this proposal. In the course of our 16 I-L-y telephone conversation, I revie%.md many of the points I would normally have covered in this letter. In the interest of brevity I will simply outline them below. 1. The macroelectrode-micra-maaipulator contradiction, a misprint as you explained, however, more information is needed as to desiga, placement, etc. 2. Since the dog skull is--somew2nat variable, what criteria for s'-@-i,-aulating electrode placement will be used? Will you be using a standard reference current to eliminate variations due to position? 'If you feel it necessary it may be wise to discuss the problem. 3. The problem posed by possible contraction of the spleen. 4. Organized2 criteria of effect, I.e.,, behavioral, anal-esic, anesthetic, etc. S. Use of descri?tors and measurements of waveform, i.e., rise time, 1)eal"- duraticni, decty tim, etc. Re"ardinS those problems the riost severe test x,,-ill be to orr,,aai.ze@Suitable Sca2l@c for judgin- the ef'Lect of electrical stimulation. This sociion in particular needs e-.Kpansion and refinemcnl. Do not hesitate to use references to establisii nreccdcut. It seems to mc that some care will have to be ex- ercised in th@ or-anieation o@' thcse criteria Lo prevent t,ic final stL-x,.ary from dooencratLn;,- into an mecdotal su=iai-y of a series oj'@ case histories. .2- Since thd mode of ainplication of current through the electrddes effects the state of the animal, I wonder if you intend to standardize the procedure of turniua-on the current. What will determire the maxim= currenl". strength to be used? W'tiat considerations will determine how fast2 you will approach this maximum? If you proceed tlirough a ranae of intensities, to a fl-ted maximum, will you be prepared to record transient chan"es which miy occur? I understand your situation, it uill tal,.c tv?o months to §et the pporram underway. Once startetl yo-i plan to use 5()C) clof,,--, in the co%-rac of the mmt tan months. I believe you also plan Lo re-u!,,! t'4tL-se eML-2--ilo %,,@hcnc-.,cr possible. within the constraintu L-npost!t! i,y t.i(. Consequent',-Y, I lt3-:o ticx2x. of prior manipulation. be to complete your study as outlined in tli(-- ilrrt. ycai-, tecti able joined by others in wondering about the details of your ;,rOLOCOI-. 2 h aoi these questions may be answored beat by further discussion in t a b y of the proposal. uld like to address T. have finished with my specific co=bp-ntsi however, 'I wo a few words to the general problem of getting elcctronarcosis research 2sponsored. Because of ths-recent history of this field of endeavor, spotty-ness of performance and redundancy of the work LL will be difficult, this subject area will have to at best,to sell. Consequcrtly, proposals in tod and realistic in SCOPE to receive support. As be complet2e, well dOCUMen the telephone, I 'I told you last Or-toocr @and reiterated on @believe this study is both needed and wanted. But to receive any but sory attention it wlll have to deal with well-orgunlzed, hard-headed cur research. Even then, it w2ould be foolish to promise support of any kind in advance. With this in min4, I would like to ask you to &alm this proposal as a starting point, detail out your research plan, and place it within a docu- mented frame%iork. if you have any need to call me please feel free to do so. In the meantime, 2 t Area Code and I may be reached during the day a equire. will be happy to give you =y assistance you =7 r RcgardLnp,, your question-an institutional overheads 1, can scarcely be considered an autliority in this arna. Howevers, in-'Ofar as I can 2dete=inel, e any effect on the acceptability this figure is negotiable and viLlI not hav of the proposal. once again, I wish to thanil, you for your effort in preparing this proposal. I am lool-,Ln- forward to a continuation of our commmication. 7 Sincerely. . .....................