13 June  1966
              MEKORMDUti FOR FM
              SUBJECT:  Project Proposal by Dr.
                   1. The basic research concept is-well planned;  however,  the  following  sug-
              gestions come to mind:
                       a.  I do not recorarend the exclusive use of dogs--actually 1,100 in
              number.  During the pos2t 5 years, there has been considerable research on electro-
              anesthesia in the U.S. with animals of all kinds. In spite of  this.  effort,  lit-
              tle is applicable to electro-anesthesia in the human.
                       b. Preliminary investigations might well begin with  the  do-  in  order
              to develop technics peculiar to inducin- electrc-aneathesia  and  in  monitoring
                                                    2  0
              the condition of the animal during and after passage of electrical currents*
                       c.  Pollowin- the use of a reasonable number of dogs--perhaps 100--the
                                   0
              research should be directed to the rhesue monicay,where the subject can  be  used
              repeatedly day after day.
                       d. As soon as expedient, the observations should  be  transferred  to  a
 2             few chimpanzees, which, like monkeys, can be used repeatedly, varying the
              electrode placement and nature of the electric currents 'With  continuous  monitor-
              ing of the aaimal.,
                                 y, concurrently.-with observations on the  chimpanzee,  human
               u jec   may be paid volunteers or perhaps patients in a psychiatric  ward  of  a
              hospital,.
                  2.  Comments re numbered para05raphs in prop
                                                              7,
                                                                                                                         13   June   1966.'
                                                                      Dr
                                                     'NO
                                                         -comment-
                                                     Implantation      of   six   c2hroni'c;electrodes             within the   brain     t
                                    the  *Joe   tr:i'a    curr.ent'p etc *': may  we  I  1           influence'the-c.urrent distribution
                                              perhaps         models could   be        used.for these,studies.
                        i.u  the  brain#,
                                     2f.   V.B6-,-@!: Why. not consider                        slactromyographic.recordings   in case   tlii-'
                                  or      'is@'stimulated.''        Also,'         elacttomyogr
                               @c   tax                                                       aphy should       be   of  value
                        deter@@       '         t2he'r'slaxation   of =nclea     desired       in  surgery.-
                                                                                                                               thesia'a're
                                                     Methods     for            determination.of  the-dapth     of   anes
                        redently      unsatisfactory.          .Pinching     the      car is  used frequently-with@tha                
monkey.,2.
                                          V#R        Post-operative               observatidiii in
                                                                                                    Boma   cases     should    be       
extended"
                        for
                              eviral',da'
                                                     -Sugge   ted-wave     fo= combinations-7seem        2               
unnecessarily.cbmpli-@@
                                                                                                        'for      animals,    why plan.9
                                 --Sinc6'thers'-seems         t6'be-a     species     difference-                                        uch'
                        estd, i@'
                        a,complate-scri2es-of                       wava'fo=,coaibinations    for studies   involv;Lng          only@doge.1
                                    C                th    '-bu      for@this'proposal'@too'=.iny                d'ogo (1,100).and       un-..
                              3       ancer'nl@ng       e
                                                       2                                                                                -is
                        necessary     surger7.,ar@-p@'annedo           Vo  continuous            recording equipment@'fbr       V.B..
                        listed--only              indicatin%z@inst-i   nts,
                              4.    if :L  rec'a      correctly,,      thei  statem2ant      vaa'made'    that     I)r.         tin    
2..years'..
                       @'.will obtain.a,PhD-d@i                                                                 I'Le, a we
                                                     greei -in@ physiology,                Although Dr.                         
ll-qualified,,...
                                     2                                              -oneathesia,witha
                        D.V,,M. and.'experienced in.electro                                         nimals,,      will there    be a       
ne=c@@
                        physiologist consulta'n't- in the proposed                 prograta      of researth?        Also,.  'a-Alectronics'
                     -,engin2eer should be available#.,The Project                       Proposal     does      not-list      the qualifica-
                        tions of.Dr,
                                                                   lor-any          of'the'tachnical          assistants associated with'-,,
                        the program...,-,,
                                    I  hope   my         comments         are'not'.@interpreted a2s  opposing       the                f
                                                                                                                       awardin,,,-, c    a,.-,
                        contract, to    Dr.'                                                                               rienced     in
                                                            ):He'-is higbly motivatedi'-intereated              and expe
              2          the  field-of     electro-anesthesia           and.1 hope       that   he   can  modify his.program             to
                        nc ude -some      of  the@xuggestions          listed    above*.
                                                                               2