KKULTRA Su@-Project 47 Descrip'ion Date: Obil,gati Fxpenditure Balance q5EP A IP55 YR- -Priject gftroject 4T L@ate Initiate4i 24 Ysmh 1955 Date 3. JtLia 1962- run,'-ts-curreat yc!Lri 430,,740 2 rurix>ml Fbambcological &na clirdeal-teattng In ania., and -volunteel--s of chem-IcalLs and alter-l>--bav-10r, piLO di@* cors%Lltation Sta2tust St'L!dy CO@-- 'hold dos--,s or j@SD-2@i,.a mthod for ,Plete4 on thrt--s- exl?loi-inz antz&oals!3 vr this d,-,ug by othi.-r-e,&ents. 'Wo@x h" b.--ca t-0 c8yaltl,-.te b@ivlng on alm'No]L Itke effqct on bebav-lor vill-b,-, Of'-effeCt45 Of c@cmbir-atioa of dxu&s of lnterist to rt,&D to V4 cc.,,niatet@ ----- ----- Lf 7- Lif inritt atcrorij BUREAU OF RESEARCUI IN NEUROI-OGY ANID PSYCHIA-RRY- C/O NEW JERSEY NEURO rsyc"IATRIC INSTITUTE BOX 1000 2PRINCETON. NEW JERSEY HUMPHRY CSMOND. M14CS. LI@CP. IDPM March 25, 1964 C- Dr. Attached is our 19G3-164 repor-@land proposal for continued research supr-oi@t by for -,.he coming year be- ginning -June 1, 19264. We hope that the report and the pooposal meet with the Bo"d's approval so that you can advise us positively tvben you visit us in the near future. C- shall be in S,3Lturday and -Sunday, May 2nd and 3rd. I can report in on Friday;-May Ist in regard to a possible conference if this is necessary.6 Our financial report for the present grant year vn.11 be sent shortly, af ter %June I1964. Yours sincerely,--- Carl C. Pfeiffer, Ph.D., M.D. liead, Section on Pharmacology CCP:tt enc. Date BEH"IORAL ACTIVITIES SUPPORT Vla Behavioral Control Materials Brancli-- BB Category-.. (formerly Ilb) N.A- Ite.-a Classification--- N. A.. Project Title------t-2-- @IKII@LTRA Unclassified Project Crypto----i--@@ Crypto Branch Project ]\To__ N.A. Project Engineer__44@ Contracto'r@@ Dr. C. C. Pfeiffer Subpro ec@@ 41 A. Contract No.___@@ 47 _Task No.--.-- 'I'@,pe of Contract- @IKULTRA Date Inita4led--.- N!arch 1955 d April Cost-@@$@55. 000. 00 Cor;iple'Lion r -a'!C'V'o 2 Purpose: n animals and For 2pharr,-.acolo"xcal and cliiiical-tc-sting i 0 volunteers of drugs alterin- behavior. St,3tus: Clinical testing progi-ains involving evaluati,on of speciil- izeo inaterials-are proceding according to plan. R'ecu,rernent: Internally generated in TSD. 7 r 11@IAL -v October 1963 Date BEHAVIORAL ACTIVITIES SUPPORT BB Behavioral Control Ilateria 2 (Vla), Branch-..- Category (formerly N.A. N. Project Title---- Unclassified Proje@-t Cl@)Tto------@ AICUL-IRA Crypto 2 N.A. Branch Project No--- @@- Project Engince Dr C. C. Pfeiff0t Contractor- N@A. No..@ Contract 4 a, '4pe of Contract 2 Date Initiate rch 1.955 Cost----.---$25 O:Q@o coirp enewed letic-n D April 1962) Purpose: For pharinaeological and clinical--tegti@ng In animals And huinan 3 i: behavior. volunteers of drugs alterin. S4&tus: Satisfactorily terminated. Contract replaced by NIKULI@RA 144 Internally genera@ted in TSD. (Who. Fi@led In) VOVCNCR NO. l ---(Hb Poject Itein Classification.N- A.-.. Project Cr)-k)to- )@iKUI@TP-A Clyvto Classificatioil UnclessifIC4 1-1. A. Branch 11'roject No- Proiect Fnzincer, Prijacetons 14cwJcrr>ey Contz-.ct No--@§!Lb-2r-Q.!e-ct (41 Tasl, No il. A. '41>e of Contract ?,,,I@ULTRA Date Initiate4-- 195S Coitinuirig Crei-.ewcd April 16Z Cost- Completion Date--=-= 2 Purpose: For phartnacol6kital ml cit-itcal-ter-ting L-i o-airrials 4"1 hxlxi-i-ka volunt,cers c-f tlr-uge -alterlng be-'haviore Status: - V, ork r.,cbe-ittled for FY-6Z hai-beca cornplcted ani a @oatirfartory fin4 report has Leet% tubmitted. t NEW jc-rSEY hiENTAL HFAI-'RH RESEAF-ICti AND DF.VF-t-OPMENT Futio, INC. jbsEFli M. T0131N,)-l- D.. Ch-,,@Art PAILIL HAUT4. NI- D, Vke C)Iairaian HENRY P. DAVID. pH. D@ V. TERRELL DAVIS, M.D. MAURICE G KOI'T@ Pi4. D. a E)OUGLAS 11. I-JACNEIL LLOYD W. MCC-ORKLE. F'O.D. 2 t@enry P. David. Ph. D. s relary Tr@.is,.irot I Jill Lane 2 Titnton 8, N. I- t"q lop June 1, 1961 to May 31, 1962 BUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY 2 SECTION ON PHARMACOLOGY- c/o New Jersey Neuro-Psychiatric Institute Princeton, New Jersey RECEIPTS: November 1961 15,370-00 February 1962 -125,370-00 Tot4i Receipts 3(07140.00 EXPENDITURES,. Salaries & Wages--- 10,356-13 Travel 1,476-80 2 Permanent EqOipmegt- i6,794.62 Consumable Supplies 1,771.66 All Other __3@4O@79 Total Expenditures 30,74o.oo 2 c'-'.t7inC-A and the submitte4 surer Henry P. David, Secretary-Trea cb C@ir-I C.@Pf e@i f f er rh D/0/,#'M.D. Principal investi;ato;y liead, Section on Fh3rinacology mvoicz For Siarvlces ic iF ioj?,3 - 13 (1) It Is barc2'by i.r. in-,;oice.- .3 s@llb-ilroject lio. of that c*r-,@ices i@r- g @p. C, c C, tliiat a dl-tailed egerai@2bf -tle C,.:)Cl recalp4Lo is file -IB-3, tb.3t tlais bil,l 16-j@@bt-6hd correc-'. I n T,--,D "d that t-ii:tr2rof br-.s no", yet I-aL2%a P-sde. e -@-L3@,-A pri I- -i 9 6z--- (2) tt Is hereby cerk-lif@erl tl,-@t ",'his lii,.,oice P.,-a.Olieu to of rhicli ,@no dul-y t--pdroved out In c.-cori!ttnce -eitti th- I 1953 fr" th-- rel to tbz of this in N t;e .4. RF-CF.IPT 190924, dated Receipt is acknowledipd of Treasurer's Check No. 3. 1962, drawn oi-i the May .- V!!@" in t'ne amount of $25, 000. 00, payable Receipt is also acvnowledged of Ti'-@asu:ter Is- Check. No.- Y400026, dated May 3, 1962, drawn on the in the amount of- $1, 000. 00, payable t ulzr DATF.-@@ Lk--k-.@ Z3 April 196Z n- tork- MY-V.ORANDUM FOR.- CW4@f, Ft ance DiYI3 VIA: TSO/Budget Officer SUDJY-CTT ',,-'-KULTRA, Subpr -ject 47. -In YO C Allotii@ent No. 2125-1390-39OZ 1. ravoict No. 13 coverln th,- aboye subproject atta hc-d-' & I c Payment ehoqld be made as f2ollolvs- CasMorl -a- chec'i I_rt the w-tioill/Int of $ZS, 000. 00 bank. 4&rawn *@.i a Cast-tter Is --chuck-I $ 1. 000. 00 drawn on Cliacks should be x2@ri"o payable- to-the 2. Ploase forvp-rd the checks to Chief, TSD/Bio)oZ[cal ]3rancb tbroug'h TSDIBudget Offlcer bi- IS b@-ay 196Z. 3. This Is a fi-nal tnyolceo H,.@wev-cr, is "tici;?ated Ill be obl2ifated for this project, the filt-9 alictild that ade-ition&l IxnJe w tiot be closed.- coo. 0 4 VI o @ q y vC'ci 0>-G 0 C H F- r. t@A- IN -riif- Al-ILIIJNT--U2F 7L Chief TSD/Blolo&lcal J3r&nch-- 24 A P6n Atttchtd: Involcri It Certifications I Cl @Ti! I I'@T C);D Distribution: 'Orig. & C C I t I TSD/FASS 2 TSD/BB TSD/BB-.4013, 4 7 i-Zi L- u r tT,.i;@cr tll.,z ty 1-n ti@,- Ca@ei 13 k'o:,A'L 1953 of t'@is ai !@o i'y @.a s -b- c-i t'@ rl t,.- the J)DIA.- e@:!d tle e-7 l@ a ,ed C,'Id $2 6. 000 Clo ite 2 1390-3904 Di-Ljich TSD TSD/FASS I - TSD/BB cclit TIAL b7 75 DRAFT 12 April 1962 ME?@,IORANDUM FOR: THF, RF-CORD SUBJECT, MKULTRA Subproject 47 1. The purpose o(t]-iis stibproje-ct-47 is to provide 2fti.nds to continue 1 C.-Pfeiffer, MD. 'h program being carried out by C a researc ar 2. The nature of t'he investigations to be-carricd out under the direction of Dr. Pfeiffer encoi-i-ipasses phari-tiacological and clinica.1 testin2g in aniiiials and human volunteers of and biocpiejnicals which alt@&f- .behavior. Certain phases of other problems of intere_st to TSD will be investigated. 3. Dr. Pfeiffer is located at the N6@W Jersey NC--uro-Ps--ychiatric Institute in the j3ureau of Re- search in Neurolog"n,-l Psychiatry, Princetoll, New Jersey. 4. The funds for this proj&tt-Will be transferred using the ---us a cut-o@,t. 5. The cost of this program for a period of one year begifuiing I June :11 196Z will not exceed $2Z5. 000. 00@@@o this suix-s ixiu-st be added $1, 0'00. 00 representing a 41o service charge to tLvvsmdw,.@ m.-+kiiig tlte total amount $2 6, 000. 00. Charges s)-toll.ld be ri-iade against Allotryient No. ZIZ5-1390-39OZ. 6. The New Jersey Menta.1 14ealth Research and Developri-ient Fund Inc.. who administer the grant have agreed to prov,ide the It 0 r Iy of 7 75 C, y "'7 7 C, from with a sum!Fry accounting on an annual basis of all.monies receiveda ded funds so agreed to retuxn any unexpen tb e They- have a] as2 soon as possible upon the close of the yrant ye ar. to t be trem @or a six i-i-ionths' infori-i-ial accounting on the part 7. The requ' ent f of the principal investigato'r is @;,aived. 8. -Title to ,ny permanent eqxiipitie2nt purchased by funds gralnted the New Jersey Ne,,iro-Psychiatric Institute shall be retained by the Institute in lieu of high overhead rates. 9. In connection with travel vnder tnis project.- it is agrecd that the Agency will accept t-Yie travel documentation and accounting which c.onforrn with the practices of the New Jersey Ment2al Health Research and Development Fund, Inc. I 0. It is agreed that tecl-Lnical reports reflecting the progress-of -the research prograi;ii shall be submitted at D-lut.ually'acceptable intervtls. 11. Dr. 11feYfer has signed the Memorandum of Agreement and holds a TOP SECRET Agency Ser-urity Approval. 3 w TS al ]3rai-tch APPROVED l'OR OBLIGATION OF'FUNDS: Date,: 2 APR 1962 Distribution: Original only Attachment: Proposal & Budget 777@7@ RU-0,EARCH PROJECT APPLICATION rranl reriocl, Jtine :L 1962 through May 31, 1963 mans of chemicals and bi(>Chemi- PROPCGAL: The testinq ill,@'@inimals and hu 2 cals wlilch alter behavior Pharmacology PLACE: Section on and Psychiatry Bureau of Research in-Neurology pew Jersey Nouro Psychiatric institute Box 1000 Pt2-:tnceton, New Jersey PRINCIPAL INVESTICArt'OR: Carl C.-Pfeiff-er.1 Ph.D.--J-M..D. M. D.' CO-PR7tNCIPAL INIIESTICATOR: GRWF ADMMST.RATORi.-- New Jersey @iel-ital Health Research anti Development 2 Fund, Inc. I Jill Lane ' Tronton 8. bt@"ersey lionry P. David- Ph@D.-@7Secretary-Treasurer INT-RODUCTION: Our research efforts have received-16nl attention and approbation during the past year so that we now have excell-e-riV-rapport with the sta2ffs of both the Institute and t.hb'B600htown-Reforinatory-. 1,,Ie now have 10 volunteers per week from the latter, and we have a Clinical Investigative Unit ,)hich will house 80--schizopbroriics (present census 45 patients). Current Status of the FliarmacoloV pni@ Th2e laboratory is still undergoing minor construction, but material progress has been made in the past year. - The section for animal screening and conditioning is complete. The sections for animal neuropliaripacology and clinical pharmacology have been constructed anti put into operation, andan electronic workshop has been set up. All these 9units are actively at work in human and animal experiments as outlined below. The f,@,oilities V r'_, D of the clinical unit---exper-imental %iard --- are nearing completion, and are-already in ictial use. Still in varying stages of construct on are the biochemical pliarinaeology and medicinal chemistry ,inits. -Personnel4.- Sitid6 the last report, the sectloh has been joined by Drs. 2 C, and*14!4n:@.. as planned. It is anticipated that two to Lhree more investigators at the doctoral level will be needed, probably one more cli-nical pliarinacologl'6t, a medicinal chemist, and a biochemical pharnacologist. Two engineers have been employed for design and 2con- struclion of new equipment and six lab assistants are-now fully trained to their various jobs. flul,nan subjects: Liaison with,NTq-w,...T@rc-@-ei--State R6formatory.---.,Borderitown has been excellent, and a full 66ffpleirient of volunteers from that insti- tution ha2s been freely availabld@-This group may be a better g-coup for this kind of research, since they may be closer to the normal population than were the Atlar-ita prisoners, the latter I)eing-recidivisLs and older than the -Bbrde-ntoW-n'group. In addition,, other human lioltinteers have been recruited, including female 2 subjects, so that the population of flnoi@inal" subjects available is now much more nearly representative of the population at large. In addition--it has been possible already to 31 begin explorations with the psychotic p.3tients_fro,-n the experimental %,@ard, and so)pe interesting results-a2re already forthcoming (see below). Equip,,,ent: 'Since the last re orti the sectloh has obtained a stereo- p taxic apparatus, a Grass Model III EEr,, and a Sanborn 2000 magnetic tape Data Recoi,der:. In addition, we have constructed Lwo new integrators for quantitative EEG; these are modeled after2 the 1)@o'N6cRi IrtC674i@-a-t-,be; but due to some circuit changes are more linear, and have the adv,3ntage of-using all Ur, parts, so that maijiteiiaiii-,e is sirt,plified. Two more integ-i,ators'are under construction which will a))-@w sij;iultaneous SE;, 1 VED 3. integration of four leads, one frdin each lobe of a hemicraniuxn. Also u-nd,-r-C-C)Ilstruction is a quantitative spectral analyzer for use with the well as electrical tape recorder in analyzing scalp E2W of liumans as measureffients from ittiplanted eleclrodos in cortex and deeper st:ruct.tires ata will be entered on punch cards and processed in brains of ani)nal-s. D by a digital coydputer. Target date for -t)egi.nning calibration and stan- dardization is june 1, 19622. 'These new approaches allow determination with great accuracy of effects of various classes of coimpotinds and the ijiteractions of such agents A Barber Colman gas etiromatograph has been installed and a technician is being trained to operate it. This-ml--Ikes-possiblo correlative studies of changes in brain c2onstituents, changes in behavioral state, and electro- physiological data. This n@etliod is far more sensitive than previous techniques, and allows accural-e measurefrients to be jrade from much sma3.ler brain fractions. A Beckman pli uteter-and micrioburette have also been obtained for study of chol,inesterase aCtiVity,-Sil-kCe it app2ears that psychotoj,-timetic effects frequently if not always involve C-ittopine-like 950) drug action (Pfeiffer, C.C.,-et al. -Nleur@ology, 9- 249-250, 1 Recent an,3 current Droiects.- These new techniques, together with the unique availabil-ity of hu2man-subj6tts both normal and abnorjnal, make possible a wide range of investigations on any class of con-pounds with action on the central nervous system. These can begin at t'he ;nost basic level and niove progressively to a level of sophistication beyond that of .ali-..ost any other setting. Soj@e idea of the directio0ns currently being ta'@.en are indicated in recent and current work. Enclosed are-@,epririLs of public--@ions during the past yea-@,. The follo%..,;ng are also accepted for p-,j'blicati-on and. ,,,ill appear in the next f e-.4 Fi)oriths: s@cz-c S 'VED 4 and Pfeiffer, C-C Use of nor I subjects nfereiice) Clin. biarmacol & Therap for testing drugs (Upjohn Co At the Federation rieetings in this month, 2 I C. will report on and Pfeiffer will report on, Quantitative el.,ectroencephalographic ap.-i _jy@is@of acid diethylamide (.L.S,D-25 and d-Ainphe@taiii-in4 in ih@n. At 2 and in @,lonieb Dr. Pfeiffer is givirig--a p,3per on, Fu@@",@r@__qy@rititative electroencep@alo- graphic studies-of the stimulant effects of deanol and d- amphetamine in man-.- Abstracts of these four papers are enclosed. In addition to the abovdl, which are ready for formal presentation, the following are under-uay:- A nun6or of tryptamine derivatives are 4p being explored for psychotoinijrietic and other effects; 4-hydroxy-a-metbyl tryptamine, 4-methyl-cL-niethyl tryptamine, 6-hydroxy-N,N-dimethyltryptafriine (T2he di-methyl analogue of Szarals-cofftpoui-)d.). prolyltryptamine, psylocin, and acetyl tryptamine. Results will be -r6i@@ 7d@@- they accrue. The central actions of @l-aiiiiiic@',)utyric_acid_.are-being ind-'-Zr,ectly explored by investigating Y-buLyrolactone and y-hydroxybutypic a2cid. Unlike GABA, these compounds readily cross the blood-brain bar-rier., and thetl.atter is a potent hypnotic agent and about as active and positive as is chloral hydrate. C- as reported an allnorwal EE--@ response to intravenous tbiobarbiturate in schizoplirenic's. Our quan1titative niethod shows no difference as yet in response between norrals and schizophrenics. to the intravenous injection of tliiopental. SOURC Research Proposals ight bl@ the abovie, the followinq are planned for the comin4 year* Tn the-I 1. Screening of tryptantine compounds in animals and jran for balluci,no- genic action. 2. Completion of the study of the use of riboflavin as a trace 2 chemical to prove the ingestion of u@edication in a clinical setting. 3. Fur@her studies on the use of phenoxybenzamine and other advehergic blocking compounds at antidotes to-JiSD-25. 4. Further refineittent of tb6 us6 of quantitative b@--ain wave studies to diagnose schizophrenia and to determin2e the delion of hallucinogens. 5. Selection of one o@v ittore of a series of stimulant diamines for chronic toxicity studies in animals so that they can be tested in normal human volunteers for possible stimulant action. 6. A search in brain extracts of rabbits treated with Tofranil (iinipra- mine) to determine if any stimulant amine accLiii@,,)lates as a result of degradation of the drug molecule in the body. 7. Deter@mination of the anti-etiol.inesterase and ai-ninoxidase inhibitory el'fecl of the stiiriulant diamines. 8. Assay o@a,cet@l,@lioline content of various portions of the biain afte2r prolonged administration of deanol. 9. -ilie assay in man of an intravenous analgesic solution cotposed of ritori)hine anti cholijic or moi,plilne and carniti.ne wlierei.n the pliarma- cologically neutral quater,nary compound prevents the engagement of peripheral receptors by the morphine. 6 'I N G @kgli C F- SOURCES 10. The use of stimulants to prevent the blocking of conditioned behavior. 1,1. The use of parasyjrip3Lhotic stimulants and methylatropine to interrjpt -trained be.@avior. 12* A study of.praelical drug antidotes to atropine-.I.ike compounds. 13. Careful study in7 norgial man of A. s ynLhesiZAE@ comr>ounds B. Coritpoui-itis supplied bg@ the C. Biochemicals purchased Note: For elaboration of methods see the 1961-1962 proposal. "CE DS 0 7. Research Project Application Pfeiffer Requested Budget June 1 1962 through May 31, 1963 Time Amount Principal Investigator, Carl C. Pfei2ffer,-Pl,.D.,- M.D.--- 25% 4,ooo.oo Co-principal lnvestigator,S-AW 25% 3,000 00 C-- Senior Research Scientist U H.S. 25% None Neuropharmacolcxgist, 50% 7.0002.00 Technician 100% 4,803.00 Secretary 2,5% 1,300-00 Stipends, "uman 'Volunteers, 50 x 10 x $3.50/wk 1,750-00 Equipment 850.00 Consuin,-ble Supplies i,goo.oo Travel to Scientif ic Meetings & Conferences- 950.00 TOTAL $25,550.00 In I ieu of overhead. the New Jersey Mental Real th Research and 5 Development Fund, Inc. will retain title to any equipment which may be purchased under said grant. @TICE (i@S SOU.:@CE. 5 ff*Crii4VOLVED of Xcitl afrr.-;flii 13UREAU OF RESR--ARCH IN Nt---UROI-OGY AND PSYCHIATRY C/O NEW JERSEY NEURO@PSYCHIATRIC INSTITUTE Box 1000 PRINCETON. NEW JERSEY JOSEf2'R M. TOBIN. M.D. r)IRIE"Clt March 21 10@62 Dr. Attached you %.Yi.11 f i nd i n t-e-ri, -M -r- -e- -p- -or tof our expendi- ,@i, @ U f turkes from the rom the p;e-.,iod be2gi.j-ining ,June I., 1961 and ending I-lay 31, 1962. This brings to mind your promised trip to see our labora- tory and the progress in our research efforts. We hope that the month of March will afford you time for such a visit since we now I-,.ave much to show you. With best regards, 4 Yoors sincerely, CCP:mc Carl C. Pfeif/er /A.D Head Section on fharir;acolo' gy Period Endiilg Marel-I 1, 1962 Perinanent Consumable Personnel Salaries Travel supplies otber and Wages U-@ $ .1.@-47 $1,1.82.44 447.30 $ 45.35 2$1,148.40 4.00 13070.80 65.09 3,418.78 205.55 S6.,39 66S.40 102.94 1 259.6S 147.71 35.05 3,492.00 2 304.61 773.83 157.71 123.94 130.37 621.13 1,095.82 654.93 "$1,613.20 @26,f.73 $6,506.97 $1,095.24- $7,730.52 Receipts $30,740.00 1 17 210.66 Expen(Jitures Balance 13,529.34 BUREAU 01: IZESE@AT@CH IN NU--UROLOGY AND PSYCIIIATRY CJO NEW JF-RSEY NEURO-PSYCIIIATRIC INSTITUTE - BOX 10-00. RINCETON. NEW JERSEY JOSEPH M. TOBI.M. M.D. 2 March 2 1962 Dr. Dear @ou %,iiL find in@Le "in repoot of our exp,-n'di- per tures icd be-qinning Lc6i and-en@!ihg May 31, 2 June 1 1962 :nise to rL,:nd-your pro d trip to see our labova- tory prcs:-ass in our research bl'forts. %-le 'hope that - '- the o-f March will af f ord-yod7-t'ime- f 6t@- such a visit since 8 we ro,.i n@uch to show you;@------ b--c-t rega---ds, CCP:n,c Carl C. Pfeifler,/'II.D Head, Section on Pliacinicology-- Att.-(I) Period Ending March lip 1962 Personnel Salaries Permanent Consumable and 14ages Travel f@q@ipment- 1>plies Other $1,148.40 l@47 $IJ182 44 $ 447.30 $ 45.3S 2 1,070.80 GS.09 3,418.78 205.55 4.00 665.4Q 102.94 1,259.65 147.7@l 56-39 31492.00 304.61 -773-83 157.71 3S.OS 130.37 621-13 11095.82 -F,54.93 123.94 $6,506.97 9$1,0135.24 - -$7 1730-52 $1,613.20 @264.73 ,Zeceipts 740.00 $30ap Expenditures 17,210.66 Balance -13,S29-34 NEW JR.RSEY MENTAL IIEALTH RF:SEARCti AND ur7.Vr-LOPMENT FUND, INC. JO'@;EPH M- T0131N. M.D, Chag'rman - PAUL IIAUN. M- D.. V;ce CAA!ri,'-n 0 IIFNRY P. DAVID, V. TERRELL DAVIS. M.D. 2 NIAVRICF 0. KOI-R, Pji. D. 0 DOUGLAS 1-f. NIACNE-IL LWYD W. 1.1c@.C.ORXLF-, PH. D. Addieis C.,Drtespond#nce to; Itenry P. DtvK Ph. D. Sfttetsry Tres surer --- - I Jill L4ne October 211, 1961 Tiertton S. N. 1. 2 11, e! D r Tt la with pleasure that-l'acknowled&6 your recent con-@.ributlon of @1.5,37OiOO as the first pay-m6nt on r,,-ant-7uhder Dr. Carl Pfeiffer. OLirs Sit-icerely, Renry,@ P. D,,Avid, Ph.D. Secretar.v-'Ti-easii-ver HPD: c L' eel. Dr. Carl Pfeiffer Co,4tt,'b-if,ons sic D5@dtct,bl&- fot Feectal IrKoF,@c ?&I rUr,-GVL rA 2 ci eu 2 PO 0 2 Ot 2 tv Po co 2 9< 10 2 te. 04 2 gc 2 0 OD n 2 OD C- 5 ol ry .oat; 0. Pfeiffer, Ph.Doi M.Do to Carl June 1, 1960 to 1-laY 31, 1961 Recipient ent 'P'und as the w.i.th Ilew Jersey '4ental FP-alth Research ari-I Develo,@5M. Rece!Dts Sep@LLe.@ib e r1960 J a ary ,Vay, 12..37h.50 Totp-I -eceipts @,h98.00 w,'fpenditi-,:-e@s T-.-."-,or;k',,or.y e(Zuiomant and suoolies $38,0632.64 6 .57 id supplies-- t a. P018 2 21888.86 IP555-38 402.55 T, o 1 e"enditu-nes SL9,L.93.00 cc. Josep@'M. Tobin., Director, ':-',ireau of 9 David Nc-n.-y, See 1-TeRta.1 Hea 7ient nd 1.',h Research a-nd Develop __JD. Nt:W JERSIEV ML;-NTAL tiCALTH LI iz RFSFARCH AND DEVELOI-rvIENT FUND. INC. L JOSFP]I ?-I. TOBI.-i. M. D, Ch&Trrr@in a IALIL HAUN. NI. D@. V;c@e Cha2t'roun a HENRY P. DAVID. PR. D, Secfetitiy Yteifut&p V. TERRELL DAVIS, M.D. MAURICE G. KOT-T, Pli.D. 1:>OUGLAS H. NiAcNEIL LLOYD W. ?.14-.f-ORKLE. pH.D. Address Corr,-sp*nl*rct to: Ifenry P. Dovi4. Ph. D. Secretary Treasurer I Jill Lan* 2 Ts antan 9, N.,I. 1961 I-,'ay 122 Director Dear Dr. tail 2 it i3--&-Iq-o-asuro-to acki-iowledge receipb - - of your chock In thousand tl.iree hund--ed Seventy _,four-dollar-s-fknd fifty cents ($12,3711.50), ropr2esei-iting tho' fourth pr.ymonb supporting the reseaz-ch program of Dr* Carl C..Pfeiff6r.- Ydur"iKco"ly- Henry-P;7D"id- Ph.D. 1 0 Secrotary-Treasu.ror HPD/Im CC,. Dr. Carl C. Pfolffer Dr. Joseph Tobin- 7=i Z. 12 3-all :% FOR-@ - cm er, vix 2 A IZ' suDJECT -kIZ5-1390 tho vlb@ove ioubproj"t le at---it i;houl 2 Payr d b@o wade as to@'.Iowo-. -of 00 ura%s-,l on 9L C" iii or, el ch in t-ho a-r.-Io-,mt of $10 Z'fs,9.60 dza%M CLn ch4to..!! obo@jl:l to tho C @o to tba cbq6e! mta-r by ?14 ;,ay 1961. 3 T'oig 1! -a fL--A I -tnto It loi oblic,,,-tzz-d for t4i:s act, aft ri bc4ld ni@>t bD CIO ed. 2 t tole Chici r%/Rc-o4c@arch 13r,%nctL Otis tCI Z - -,T 9 TSD/J@B 'RSDIRB. nvoics For s@_lrvlces - - - - - - - - -- - - - - - - - - - --- - . . . . . . . C F@@i-3 -1,'l CAT I 0,';S (1) 4,lt is hemby certi-lied that this is invoice applyil%g tc, su'b-project "at re beine, 0. of toljL-I;RAR that j-,vrfor@c@,-nce is satisfactoryp th servicea a ncc7o'iA@i-shel 3'.n accordtnce imitual ar;,Lv2erents, -tbat a detF-,Ilcd aperida of the ley-xents f.-nd receipts to on file in 'I'SO/n that this bill ic- just and correct F-Tid th4t lay-,Tent thereof hv-.e not,yct t-cen itme. 'eirch Bra-rch z Date: 4? (2) It Is 'ica@eby cartified this invoice al)@olies to S-,jb?roject of YVUL-TRA. v@,ich up,s duly P-nd2 that the c@i-ried out 0 -project Is 'teiiig r in accordp-nce' vith the meic-ra:-ldu-@im of 13 April-1953 frc.-Ca the DCI to the I)DIA, ani the extencion of this Eiu'L'hority In aub,,7equent Rcbcareb Dirvctor Date:- -4r O. rip V;z fad 4i I June M FOR. COMPTROLLER MEMORANI)U FirjAllce Division A'I-f ENTION 11A. Subproject:47, Additto.,vat SIUB2JE-CT )AKULT No. 9 Authoritat On randurn dated 13 Aprit under the authority granted In tlle melflo nslon (>f-tbis authority 2 o DDIA, a-nd the exte 1953 from the Del to th ed Rnd da subproject 47 hqs been approy In subsequent rnemoran over-all MKULTRA-proje-ct funds has been $3 1. I2)SO. 60 of the es This obligation of obligated to cover the subproject expcns c funds should be charged to Allotfn-etit zl@&S-1390-3902. Chief, APPROYF-D FOR TSD/Rcsearch Branc Of FUNDS: gKtCA rector ]Distribution: Orig & 2 - Addressee I - fsf)/OC d@,--FS D / F A SS 2 'FSD/RB PRoPOSAt. SUI Testing In Animals and Human Volunteers -of Chemicals -IJECT: The and Bl,ochemtcals Which Alter,Behavior. ychiatric Institute PLACE: The New Jersey _heuro Ps - ogy - d Ps 2 The 13urcail'of Research in Neurol an yehiatry Princeton, --Nlewjersey (P.O. Box 1.000) CarIC Pfeiffer--Ph.D.. M. D. PRINCIPAI, INVFSTICATOR N&w-i rsey Nlental Health Research and GIIANT ADMINISTRATORS: e Dc%,elopiiient Fund, Inc. I Jill Lane, Trenton 8, New Jersey Henry-P. David, Ph.D., Secretary-Treasurer It is proposed to conduct screening and range fi'ndiiig tests on volunteers with chenitcai compounds of known beli@-Aviorat activity.- _Studies will be- conducted on derivatives of selected biolog2ically active cotiipounds to deter- iiiine their action on the central nervous systein of -itan. In -addition to these investigations, the follouing !vork will be undertaken-. 1. Pharmacological testing will be conducted on aninials utilizing candidate hallucin6g-e-nic- che'rnicals 2 2. Stuclies will be conducted on coriipounds of relativly simple configuration to assess their ability to Inhibit trained behavior In aninials utilizing the condition avoidance respoiises. 3. Studies will be conducted of coinpounds In normal h,,inian volunteers for possible behavioral changes utilizing @o7t-tipounds provided by the sponsor. 4. Quantitative studies of the EEG In animals and man to deteimine stimulant or depressant effects of can(Jidate niater- tals. (Whet, lj'ij.d In) CONFIDr-,NT:AL FU,4DS POS71NG VOUCHER DATE - 4 v J4 NO. 7- 1 2 2 VOUCNEN NO. 7-13 4 52 5 a. 6 7 -70 71-80 DESCR 33 AS As.4 00 COST ".V2C 1PYtOlt-ALL OTHEII ACCOUOIT% 13- AO-A2 , C. 53@ Al.Loy. I PAY No. ACcy. No. 0 lp,. 3 1 coo( EXPEN 2 v 11 AL p cp CA@ K.EDGER 62 DESCRIPTION- O'l COOE N I ACCO2UNTS- 13-27 0. Llo..! YA JACCY . 000 . 0 9 a I T cat a I I ADVANCE ...... . . . . . . . . . D C00cl,@ ha.. ... ;;., , 2 C,Ass :IJ 7,q CXP@.ANAF ION OFP CN'FRV TOTALS DATE PRCPAOtcn BY mcvicwco eV CEPTIFIED FOR PAYMENT OR CREOTT DATE 777.. 1-@IF4 COf ccmylfvlt4G OPFICER 0 too-40) 10-5, 606 us% p ),z JUI)R 1961 -WMOP@ANDUM MR.- Chie(, lln@"Ce N-yiefoa VIA i TSD/Btidget 0mcor ice No. IZ SUBJECT ),Il2@.TLTRA, - Sxi'5project 41# Livo Allot-tiient 2IZ5.1390-3902 project Is attachod. 1. Inv-olce 146. I.Z covering tho abov@6 sub PAy-rzie-i-it shcmld be mado As2 follows*-- C@-"Mor's check la the AT--nount a $30,740. 00 drav-ia on a bank, A C.,-shier' o check in the amouit of $1, zzg. 60 dra'A'a ol 0 tn 2 Checl,6 !@'tiould b%dW)-abl to th 24- Pleaze for,%&-Ar(I the cl@@ks to C tl r y -.irc-uZh TSD/]3ud,.-et Oftlce by 24 ix!.l 19619 3. 'lVs to a ritia LiNbl2ea, HoW6ver.- einco it to anticip-ated -,tlif-a--project, the fi-tes that ad tto@ia fkl-ids -.@,-iU be *!>Iigatei 'hould not be @closo& 8TSD/Rciec-arc'h ]3ra,,ich Att--chodl Invoice 1, Cerafictitions Di e t r I bu ti O'l.14. Orig Z Addresoce (Who, t7j)i,d ]A) A CONFIDENTI,"A' FU@NDS POSTISG V 0 X E? VOUCHER NO. 7-12 DATE 2-6 ivOUCHER NO. 7 a 0 4 7. 6 2 67 E CRIPTION-ALL OTNEf4 9 ACC2OUNTS 13-3 1.0-42 o@ 6 O&L G@. @-13@ 5 AL%,OY OR COST ove AMOOJNT COUE E .!A 2 "4' - IN .4 'A" I EF. L ACCT. NO. No E g. . . . . . . . . . OESCRIPTIO 2 62 7 0 Ale N C f,, c 0 ADVANCE ACC No c 2 UNT 1 3.- 27 0 0 YR s ............ I-ET CA LEOGER 2 c ACC7 co c 1-f W EXPLANATI2ON Of thypy TOTALS PAYM ATE P14CPARCO OY DATE 2 REVIEWED Sy CER'rgFIEO FOR LNT VK CREO@T- iFvt%G OfliCER 1 OAVE lsirkATutc 01 CENT FoRho iF" to- 5% use o,-Cvio Z6 April 1961 F hief, Fioance Divistort M, ORANDUM FOR,. IC m officer -VIA T,51)/13udget 2 avo SUBJ.ECT MKULTRA, 60* 1 lea No Allotment 2125-1390-39OZ 7-In the aniount of $18,500 tii H(5wevers---- 1. Invoice N 2 project (as per due to refund$ of $5, 58Z. IZ froviii this and one other follows'. iadp- a a attachriients) payment should be 11 IZ, 917. 88 drawn on a Cashier 5 r-h-i@-ck id-the at-liotint of $ ayable to the local'bank, liu-tn-&n@ l@coiog hould be forv,-arded to Chief, TSD/Research 22. The checks a n later than Monday, 13raiich, ihrough TSD/]3udi@-t Officer, o 3. This to a final Invoice. I-lowever, since It to ai-iticipated that addittonal filinds -.vlll be obligatcd for this project the files should 6 not be closed. Chiel t TSD/Research ]3ranch Atttchment: Invoice Ik Certifications Distribution-. Orig Ik 2 Addresses rFtoposAL d 1-turi)an Volvnteers of Cherrfcals SUPIFCT: The Testing In Animals an and 13tochertitcals Which Alter J3ehavior.. PLACE: The New Jersey Neuro-Psychtatric Inst.itute The Burea' o2f Research In Neur--Oiogy and Psychiatry Princeton,'-New Jersey (P.O. Box 1, OOD) PRINCIPAL INVES'riGATOII: Carl C. Pfeiffer, Ph. D. M. D. GRANT ADMINISTRATORS: New Jersey l@,tental Ite,alth Research and -1-)6vel6pii)ent Fund, In'c,-- l@Jill Lane Tren2ton 8, New Jersey H@w@P. @avid, Ph.D., Secretary-TreAsurer It is proposed toci:o-@ct screening and rangc flt-idiiig tests on volunteers withchemlealcoi-iipounds-o-fknoW6bel@"foral-activity. Studieswillb6 conducted o@ d2erivatives of selected biologically active compounds to mine their action on the central nervous system of ro3in. 7 In addition to tliesc Investigations, _the following work will be un(,Ic-rtaken: 1. Pbarmacological esting %%-III be conducted on villizing candidate hallucinogenic 2.-Studies-will be conducted on compounds of relativly simpl6-i.-@figuritton Io assess their ability to inhibit trained behavior In animals utiltitng the- condition avoidance responses. - 3. Studies will be conducted of -coi))poun(is in norm.-Al human volunteers for possible 4beh@vioral changes otilizing.compounds provided by the sponsor. 4. QL-iantitative studies of the EEG In anin-)als and rr)an to determine stirnulant or depressant effects of candidate rnater- DRAFT I June 1961 MF,MORANDUM FOR: TIJE IJFCORD MKUI,TRA Subproject 47 SUBJECF 'f he purpose of thl" subproject 47 Is to provide funds to continue a research program be Ing carried out by Carl C. Pfeifrer, MD. 2. The nature of the investigations to be carried out under the direction of Dr. Pfeiffer encompasses pharidacological and clinical testing in animals and human volu6te&t@@- of chemicals a.nd biochemicals which alter behavior. Certain phases of other problems of interest to TSD will be fiiv6stigated. 3. Dr. Pfeiffer Is locat2ed at the N&,-Ai--JeYg@Neuro.-Psychiatric Institute in the Bureau of Research in Neurology and Psychiatry, Princeton, New Jersey. 4. The funds for this project will be transferred using thc4vll -V. asa cut-out. 5. The cost of this prograin for a period of one year begirining I June 19612 will iiot exceed $30, 740. 00. To this sui-ti inust be added $ 1, 229.60 represe nting a 4% service charge to th riiaking the total arjnount $31, 9G9. 60. Charges should be made against Allotment IZ125-1390-3902. 6. The New Jersey Niental flealth Resebirch-and Developinent Fund 2 Inc.. who administer the grant have agreed to provide tbvolm.@ s,,rL-troary accotinting on an annual basis of all monies received iF @a IIAL greed to retufn They have ilso a frori,i the funds to on the close of the grant theol:@g s@@as soon as possible up year. 7. The requirement for a six months' informal accounting on the p@rt of the principal in2vestigator Is waived. 8. @'ritle to any permanqnt equipment puychased by funds granted the New Jersey Neuro-Psychiatric Institute shall be retained by the Institute in lieu of high overhead rates 9. In connection with travel under this project, it is agreed that the Agency will accept the travel documentation and accounting which conform with the practices of the New Jerset_@"al H -e-alth Research and D@@@lopment Fund Inc. 10. It is agr ced that technical reports reflect!nUt@@ progress of the research program shall be submitted at rnutually acceptable intervals. 11. Dr. Pfeiffer has signed the Meniorandt)rri-of Agreement and holds a TOP SECRET Agency Security Approval@-7------ 2 4 APPROVED FOR Chief OBLIGATION OF FUNDS: TSD/Research Branch Be it -Jul_ Date: Attachments: Proposal & Budget Distribution: Original Only 6 B 7475 pRop(SAL 'The Testing in Animals and liornan Volunteers of Cbe ieals SUpiECT: micals Which Alter Behavior. and Bioche ic Institute ttsey Neuro-psychiatr and Psyc la PL2ACI-,: 'f he New Jof iie'se@irch in N-elirOlOgY --- h' try The 13ureau "Y (P. o 13ox 1. 000) Princeton& New @srs M.D. h D., INVESTIGATOFT. Carl C. 1-feiffert P PIIINCIPAT- nd ntal Health Research a INISTRATORS: New iffs-ey RANT A nd, Inc. Developj2-itent Fu ill Lane, rrenton 8, New Jersey d, Ph.D., Secretary-Treasurer Ilenry P. Davi ange finding tests on volunteers-- sed to conduct screening and r Studies ill be it is p2ropo nds of known beh,-AVIDral ativity. w with cheinical compou call active con)poinds to deter- conducted on derivatives of selected biologi Y mine their action oii the central nervous system of iiian. ilowing worl,, will be undertaken, 2 In addition to these Investigations, the fo - i. Pharmacological testing will be conducted on animals utilizing candidate hallucinogenic chemic@LlS. 2. Studies will be conducted on compounds of relativly simple cDnfiguration to assess their ability to inhibit trained 2 esponses animals utilizing the condition avoidance r behavior in 3. 3tu(iies will be conducted of compounds In norinal human volunteers for possible behavioral changes utilizing compounds. pr;vided by the sponsor. 4. Quantitativ2e studies'of the EEG in animals and inan to f didate mater- determine stimulant or depressint effects o can ials. s NCE INVOLVED akt@on Pfeiffer Retearch'pr,Oj6ct Applic Requested Budget Ju-n 1961 thru May 31, 1962 E4-0 li-@ TITIP, 2 25% S booo.00 Principal Investigator Carl C. Pfeiffer, Ph.D., IA.DO 25% Senior Research Scientist, pai.i by State of N-e-e Jersey@ 75% lolooo.oo M.D clinical Ph-arr-acologisilvl-----=Mll 50% 69 @.L@ NeuropharmacolOgist, Ph.D. i,o2o% -h,160.00 Technician & knimal 35% 1, 2 80. Or) S e c r e ti- 1,500-00 teers Stipends Human Voiun 2 None Fquipinent Con5urr,able Supplies: knimalso kl)im.Al. Food, Biochenicals, Paper 3pliOD.00 f oi F-SO Travel to Scientific Feetings Conferetices TOTAL $30,7LO-(O In lieu of overhead, ttie N@aw Jersey-l@l-ental Health Research & Develop:nent Fund will retain title to arty eqaip;nent which may be p@ichased under 5aid grant. 5/61 5 w TICE NSI Sv f,'jE @vot 777777 RER_EIPT a of the following two CheCkl'- @-cipt is hereby acknowlt'3941@ Re_ 1960 drawn O,, 32ated Jiily 7. unt of O.'G4'Z7 - in the amO e 5f(icial Ch ck'N @74@@ 00, payable to $49,4980 drawn on 2 786. dated-JOIY 7, -1960# id the an'tount Of 4-? (ffictzl Check 1'70,, payable to $1, 7 9. 9 Z, V 9 Dat IL 29 June 1960 J@IENIORANDUM FOR, CIIIEF, Vli-4AUCE DIVISION VIA 3 TSD/Buunt of $21, 979.9Z. drawn or, a EAch check should be made payable t-o-the4v 2. Pleace forward the checvf-t"bleft TSD/Rescarch B-t'@h- through TSD/Budget Officer by 13 July 1960. 3. Thts to a final Is anticipated 2 that additlockal fonds will I.,P. ol,>Ilgatcd for this project.- the files should not be closed. Chief TSD/Restarch Branch Attachment,. Invoice ic Certirtcjkttons Distrtbutton: 1 Orig 4 Z - Addresece- I - TSD/FASS "2 -,r S DCB 7 INVOICE For Services $51,477.92 - - -- --------------------------------------------------------------- CERTIFICATIONS (1) It Is hereby certified that-this Is InVblce-ill aj>plying to Subproject 47 of MKULTRA, that performance Is satisfactory,-that services are being a'coznfillshed In accorda-nce with mutual agreerrents, that a detailed, agenda of the payments-and receipts to on file In TSD/RBS-------- that this bill Is just and correct and that payment thereof has not 2 yet beca made,------ Chief, TSD/Reisearch )3ranch Date: (Z) It Is hereby certified that this Invoice a pltes to Subproject p No. 47 of MKUI,TRA which was duliy approved. and that the project-- -- Is b9eing carried olit In accordance A,Ith the inetnoranduin of 13 April 1953 frorn the DCL to the DD/A. and the ekt6-"16h--bf.this authority la iobsequeot rneizioranda, Research Director Date: BY 1 5 D R A F T 20 X@a,- 1960 i'OR E RECORD 0 D Tll MKULTRA, Subproject 47 SUBJECT 9 to c-ontinue I The purp,@se!.'of this 2subproject is to provide fund a research prograi-n being carried outby Carl-C. Pfeiffer, M.]D. Z;- The nature of the-in--v-e-stigations to be carried out under the direction of Dr. Pfei,'f.@r encompas3es phar;r-acolooic3l a-id cl-.--ical iii ani-nals-@cnd hui2,-itn -@,ol,-,ntef-re of che.@nicals and bic,chemic,a,ls which alter behaxior as outlined ir. th-- attached *ro?osal. 3. I!r. P.'e;,ffer was 2reviou,-;Iy-located at the Einory University, Atlant3, Geor-'a@ia. I!e-ia-2now lo-cated--a-t-the New-Jersey-Neuro-P3ycliatric Ir.Etitute in-the PLreau of Res-e@irch i-i t:eurology aud Psychiatry, Pr',-ncet'on, ew Jersev. This -change-ii position will not in -ny %%-3y interfere with the t-cctitzy spo.,Iaocecl work, in f2act- Dr. Pfe-.ffer -will liave aece!z s to -nore - and better equipinent and perronnel for his recearch. 4. The funds for this ?roject .vill be transferred using the as P- cut-out. 5. The cost of this p,@pgram for a period of one year begioning I June 1960 will not exceed $49, 4-983. 00. To this sum Tnust be adoed $1,970,.gZ reprerentirg 4@'o service chari;e to thez-*Vxmmwmwt-@> @ej to. 74?s u "A 7 or e 2. Charges %Fawi kin thetotala t $51,477.9 a r.,i o u n should be m.--de ag.;@inst Allotment 05Z5-1009-4902. 13 6. The%Motf--@- @@as requested The New Jersey nd Developrrent Fund, Inc. , who administer Mental -Ilealth Research a th -Ubmit to them a sui-.nrriary accounting on art arnx,-al basis c2 jrant, to e clf all i-rorvies. x,eceived from the Fuod. Also, it ba.9 beet req-,ieste-Li_that any v.nexpended funds be returned as soon as possible upon the close of the gra,r-t ye3tr. 7. The reqt,.irernent for a six xi-iooths' informal acc2ounting on the part of the princip3Ll investigator is waived. 8- Title to any permanent equipment purchased by funds grai-!ted LnLversity shall be-retaine'd by the University in of high ove.-Iie-af-4 rateg. 9. In connectioc with travel under tbis-project2, it is aoreed that the P-z,2@ocy wilt acccpt the travel docut-nedtation and ;kccountina---- which con-fqrm with the practices of the University. 10. It is agreed that technical reports rcflecting the progr(,sa of the reseatrch pro,-rarn sh3ll be sti2bi-nitted at miitually acceptable intervals. IL -3- Dr. Ilfeiffer has signed the MernorandLL-n-of Aoreeiiient and holds a TOP SECRET Agency Security Approval. (,hief TSD/Chemical Branch APPROVED %-;'OR OBLI,.@-',ATION OF FUNDS: ]Rcsearcli Di@9,4cto'r' Date: AttachrA,ient: Propoeal & Budget Distribkition: Oric,inal only. ,IF I @l Al L/ 91@-13 RESEARCH PRWECT-APPLICA'TION PROPOSAL: The testing in anir.-,a-ls and hunan volunteers of chemicals and bio- i-h'@iii-ic'a-fs- which al @-er beha7vi6r. L PLACE-. The li'2e,.4 Je-rsey Neuro-PsychiWit-@lKstitute The Bureau of Research in Neurology and Psychiatry Princdton flew Jersey--(F. 0. Box 1.,000) PRITJCIPAL ITIVES-TICATOR- Carl C. Pfeiffer, Ph:D., M.O. ADMI G P.@', N TNISTRATORS 2 h'4@,t J m nt -e 1 h 9 nt Fundj Inc. e a) 8 a t ese ch and Developme ersey ar I Jill Lane., Trenton New Jersey Henry P. David, Ph.D., Secretary-Treasurer------- IIITROD2UCTION: The'4MZ=*-W=V.PAd has a-Lded-the-"search studies of the principal investigator for, r,;ore thin ten years, during which time r)any notable advances have been accc4@ipl;shed.; e__ At present the- search for newokallucinogens (chemical)--- y simpler than LSO-2@5).- These are synthesized by@tL%Zgd* tested in aniirals and in yol@ro systems and then cautiously tested in man. is -taking-a--Iea-ve-of----------- ob5ence next,_year and will work in 1961 as head of medicinal che-mistry in the FA=@ 11 6 His synthetic work wi II continue in u WFWIT testl i9Sl, and in I the backlog of conpo n2ds already synthesized. The grant to Enory will terminate as of MaY 31,- 1950, which is the close of the present grant yeat-. Other funds ai-e available at Enory to continue the testing of the@MO-Wonp,@unds at the Atlanta federal Penitentiar'y under the direction of M.D-. -frboi-thii-&riod2-J-une 1, to Dacenber 31, 1960. 8y this,time the hu,-.ian testing will be-o-rganized-@@6d-proge-dssi'ng in 14ew Jersey under the direction of the principal investigator. 0 n J u I y I I - 1 5 5 1 4Q4,tMK;M--;144 -M W-@l@ I I -3 - have completed his 2last six months of a spi I t-- internship and wi II join the research team in the flew Jersey location. RESEARCH PROPOSALS: A. Pharmacological testing in animals of candidate hallucinogenic chemicals. S. Study-of sinple compounds which n@ay inhibit tr2ined behavior such as the conditioned avoidance response. 2 C. Careful study of conaounds in normal human-'volunteers for possible behavioral changes: c@- 1) tot@@synthesized co-@ipounds 2) C(>-.i2ounds supplied bytlgl3glt 3) Sioch@--nicals purchased -WAI-@ III I--! TICE F-NCE t@-,.;tcEs L@.D I. 01-VED page 2 D. QLantitative studies of the EEG in animals and man to determine stimulant or depressant effects; E.--Annual conference on the neuro-biology of psychoses. Proposals A, 8, and C are a continuation of thvwork now in progress which 2 Om is familiar to the officers of The "n76ur annua I and s' annual reports Under C th@.'source of hurran volunteers wi II be the 100 reforttatory inr,.dtet (ages i8 to 28) who bre stationed on the grounds of the Institute. 2 if 16 volunteers, a3ed 21 to 28; a.re not obtained froi this group for a iveckly session of drug testingi we will have one session of eight--subjects at the Institute and one session at the- N6w Jiersey-S-tate,Prison@in-'Erenton. 1,Cck-@nissioner Bra,,nberg has given his peu-.,iission. . Under D we nc,%4 have perfected and plan to use at the Na-.4 Jersey Labor-itory a quantitative integrator for drug studies in both man and anirials. Adult unanesthetized, trained animals are used. Under anesthesia small go plated wood scre%-is are used as dural electrodes. TKe,@e lightly engaged 2in the calvariln and held firaly in place with nathacrylate with the permanent lead attached. The recording leads are bi-@@polar from the left and right frontoparietal lobes of the brain. The animals are in a sound attenuating box and sit quietly for the entire I to 2 hour session after a-few training periods.--- - - 2 A Crohoc3ci integrator is attached to one lead. This device rectifies the brain waves and by a chopping process, counts the area under the rectified curve. A signal is nade at a pre-set degree of- sensi-tivity. The nu.-tibcr of signals per unit tin.e is a n-easure -of the degree of cli@6trical activit2y or .1'electroG6hesis.11 The -number of pulses or signals is directly-correlatable-%.iith the area under the curve* The constancy of the el6tteojehesit with elapsed time can be calculated and treated by the usual statistical methods.- In this type of-analysis, periods as long as five minutes can be u2sed as a baseline or control aQd thus transient artefacts are eliminated. The action of drugs is usually measured at 1-5 minute intervals after intravenous injection and the drug action is expressed as change in percentage electrogenesis frorn the control preinjection period. Arousal or stlinulant drug effects are recorded as a decrease while sleep (sine %.iaves) produce an increase in clectrogenesis. E. Annual conference on neurobiolo9y of psychoses. liost previous conferences of this type h,:ive been poorly planned, and the group has been too large and un@eieldy; V.onty spent on verbatifi recording and publishing is viost6d, and this-process further 2 inhibits the participants. -. record will be in the form The participants will be limited to 12 or 15 The of the individual's c,,,in notes and the notes of a ;cientifically trained secretary. The su-,u-,.arizing secretary will chance with each three-hour session. In a two-day conference we2 v:ould have five sessions of three hours each. The conference would be held i@ just before or after,the#QMZ!-?4@ Only al disease would L-c in@'ited. The various basit disciplines would be represented. 1So-ne of the participants inight be -WA 0 1 ICF- 7 page 3 Research P iffer ental Prior to the meeting a questionnaire on possible biological factors In iii ossible disease would be circulated to the Participants, and their response to these p 2 determine the agenda and the priority of the factors etiological far-to.-s listed would -discussed. vqhicli will be included in the questionnaire are for. Possible biological factors eous clinical entity) Sq:h-- A. The ._?@o2hre,nias (assuming a heterogen 2 d 'lization 1) Defective keto-aci. utt -2) Defective carbohy&ate utilization -ithione 3) Decreased level of, ..blood glut. 4) Therapeutic effectof intravenous glutathione 5) iiicreased ascorbic acid requirement 6) Increased ce2ruloplasdiih in acute schizophrenia 7) Therapeutic effect of ceruloplasmin 8) The effect and role of Taraxein- 9) Increased adrenal cortical and nedullary activity 10) Increased urinary catechol ariine excretion 11) Increased urinary indole excretion--------- 12) Epinephrine metabolism 13) Seroto2rin 14) Thyroid function 15) Estrogen-androgen function ((-.iore co-oon in fe,-i3le?) 16) Liver (unction tests 17) Co-enzyne activity (hippuric acid synthesis) Co-enzyme A 18) Effect of gro%qth hormone a) Occurs when sociatic gro@qth stops b) Post-parLurn psycho2sis c) ACTH psychoses 19) Childhood autism and the adult schizophrenics 20) Pineal gland extracts 21) The schizophrenias in the blind 22) Sensory deprivations and p@ychosis___ 23) EEG abnoriDalitieS a) Heath's septa] spikes b) 14 and 6 disorder c) Cold(-,2ian's fast activity after pentothal 24) Biology of clectroconvulsive therapy (change in cholesterol esters) 25) Biology of insulin coma therapy 26) Specific effects of nicotinic acid therapy- 27) Spe'r-ific effects of phenothiazines 28) Specific effects of reserpine 29) Specific effects of deanol 30) Porp@iyrin metabolism 2 31) Thioctic acid 32) -tunker-stein tests 33) Response to histamine and allergies 34) Overd6sage of amine oxidase inhibitors 35@ Influence of tuberculosis, influenza) etc. 36 So-natotYPCS RNI NO' E I TEL CE 'T LVED page 4 fei r Research Project Application P Dep !less i ye p_@yoo@e!k Amine oxidase inhibition Isive,therapy or insulin Action of electroconvu 2 3) Deanol therapy 4) Blood butane- 2, 3-diol levels 5) Soatotypes C. rianic p_@_ychoses ])--Ef'ir@.@-t Of lithium 2) ti,,tabolism of uric-@ci d mania 3) HYPerthyro' 4) Neuraf,-ii ni cacid 2 5) Catechol amino excretion-- 6) lndole excretion 7) Bloo(@acetoin levels 8) Effect of phenothiazin-,s 9) Scxnatotypes 0 L E t4 ITIV SOURCI--S l@ LVED If page 5 f f e r Research Project Application Pf 2 BUDGET Time 2 5@/, 4.,000.00 .D. ----Principal-InvestigatOrl Car) C. Pfeiffer, Ph.D.,p'M 7,500-00@ Research Psychopharmacologist, M. S . I OCRA 2 12,000-00 clinical investigator 4,000-00 Stipends Human volunteers 2 1001/1 '500. Technician Secretary 5 WI; 2,G@,0.00 Animal llkan 50% 1,500.00 2 648-00 O.A.S.I. Lqy:ipent 2 Electrificd conditioning cages for animals (J $250.00 500.00 I Constant-intravenous infusion pump 2 350-00 4,Soo.oo ulator and transducers -1 Polygraph Grass 4 channel %,iith stin Consumable Supplies 2 4,000-00 Aninals, anina) food, biochen@icalsp paper for EEG Travel - To scientific meetinss and locally to-Trenton State. 'Prison -and;@gsp@-ifit' 2 1,500.00 .4iscellaneous - Photographs and reprints 200.00 Conference on neurobiology of psychosis 2,000.00 2 @49,493.00 In lieu of overhc-zd the tv'e-,,i Jersey f,'.cntal Health Research and Development Fund will retain title to all pern@anent equip.-.-,ent purchased under said grant... The above rrant is requested for the period June 1,.-1960 through liay 31o 19SI. WA l@ ol-lcf ivc SOUR,I_R r zo may 1960 'R VE:MORANDUM NTIO,,N F1 aace Dlyielock ATTY -M.KUL'r]RA, Subproject 4?, Additional 5uBjECT uthortsatlon No. rand%arn dated he authority granted In tbc-mt-1110 to the DI')/Ai-- and the e-xtcOstOd Of thl 2 13 April 195S from ths I)CI ority iq ou'@>sequent unemoranda, Subproject 47 b2ki beta auth of the ova,.r-all MKULTRfi, project foods -47?.9Z approved and $518 2 has 16ten obli@&ated to cove r the su*o roject expenses.- This p gattort of funds should be. charged to Allotx-icat 05Z5-1009-4902. obli Pf TSO/Cheritcal 13r&ocb APPROVYI) FOR ODI-IGATION OF FUNDS,. Bcsc;ktch Director r, ate: orlg & Z - Addresses I 'f SD/OC I 'fSD/FASS 2 TSD/CB 4 'FSD/CBt L V liy D--.rec-.or D-- Ci@t" Si@) r)r Pet-iocl JkLne 1,: 597t@@@ I. Ree-@i-ved fro-n 00 3(7-50 Perso-n-nel- @23.,-359-39- -ellowships 7j3OO.OO S-",bjecl-s 2 - -3,310-00 ?i-avel 2,,919.36 005.68 Di-rect E@@@@@43j6'08.42 Indirec%" Costs-- 4 -55 811. 8 D .LOTA-L I-L7uRES V,8,035.26 *See e-'.tac'ied sc7.,iei-oles .,.)-aroved: C:!rl C. P r o,.@;cD. i-ce @,or D- r,;-.'ent of IPna Dr. Carl C. Pfeiffer -Director Position--- Rese--re'.h Assistarat 224-2.00 Researc'n-2Assist-ai-it 3630 00 Instrvctor 300:00 Assist-an@t, N-ofessor 300-00 Assistant-Fi-ofessor 8,016.58 2 Associate Professor goo.oo Resep-rch Astis'Ltnt 1040.00 Re@@o"'n Technici,,ln 224o.44 .1eq5.oo 2 Resc--rch Tecbniciam Teei-iiiician- 90.96 R6s6-kth Technician 1050.00 I nt 390-00 2 Assis'flpnt 669.oo 14.88 ;dcial-Sect@rity 58 2 23359--39 Fk-"- "I., Sh'i PS Fellow 6c)o. oo Fellow 6oo.oo Fellow 2 300-00 -Fellow 3C)0-00 Fellow .?500.00 Fellow F@r.r-%n cubjects --33@0-00 1,DRY t4-]IMSITY Der.@r'.,Pent of Pi)ax---P-coi-oa Dr. Carl C. 2 Check i cl U?-l D@,- - e lniiv D e s I n i-I i o -Y I l.u!%ber A 0,,-n t 8- 7-59 8- 9-59 Carl C. Pfei@.tf@r2- l@'ewe rk, N. J. 80C)OO 8-3C-59 0- ',--59 jE-8-69 64.80 8-3C@-59 0-.3-59- C,--rl C- P' 2 1-17-75 Leil"fer OrIaTido, Fla. 814-29 P--25-59 0- 3-59 .80 2 81568 8-20-59-/ 9- 4'-59 8-2,0-59 / 9- 3-@9 Si-9-51 15t-).O-O, 10-15-59 /10-17-59 Carl C. Pfeil'fer 2 Cleveland, obi.o 83646 130-54 1-13-'O 1-14-60 88967 IC),-. ig 2-i6-6o 2-17-'Q'O Cerl C. Ffei.I'A'er !'*ewark, Ni J. 91317 168.45 -eo L) 92314 85.4.g 2 3 3-13-60 2 020'58 6o.4i 3-3C-6o 4- 2-6o Carl C. FfeifA-er -----Tltt-sburLYj Pa.-- 9 -L53 I 00. C)O - 4,-ic-60 2 a .50 9145-20 3 L--io-6o / L'-15-60 -w 95031 200.00 4--lo-6o )i-i5-60 Carl Co 95227 183-09 4- C-6o 4--,.6-4o 210.7§ SJ-24'-38 1! -io-o'o 4-15-lo'O SJ-!,-38 log.6o .-IO-60 4--20-60 ior@g@ SJ-4-38 -,@C-60 2 95&'18 1 &'4.15 -Eo 5- 9-"O SJ-5-19 ir-@.,Ic, -1c,-6o 4 1 3 0 %4"94@@ VIA i'O ft L@,DRY Lg'Pi-i@IRSITY of V -@-r:T@@cOlOal VO. NO. Fii-m -vatise service ')1-59 56.9030 2 (43 -09) -ReL-uijd of Cd5uOms i-e-rts for )c@wri-'Uer & fii,,i eclitor 85@143 68.96 85123 4.92 &"3119- 23.25 C'@.) a 1 r 2 91-39 Au@!@-o C'a-lc@ola@,Or .128C,6 1, 009. 4 0 Bat@@ery boos@ler 92,q75 11-31 1, OC)O 00 02 3 3 VaCUIL,.i cleaner 945oo -P,l e c -Lr o e? i c c p'-. a 1c I 0 99829 17-@-Q - 7' Toz @l @ y @j II-x I K-@ gig DeT@ar'-Lr@ent of PharracOlOc',y Dr. C-,Irl C. F@ciffer, Director 2 Al.]YtjNT IW. 4 VO. !iO. 38.oo ser-,,;,@ces reniierea 2 7o,391 L Reprints 76733 767377 3-71. 68.60 2 2 7 3 P', c@r-@accu-@lical Sti-i@10-iCs si-6-7o 7-32 i -ibsorp@Llion spectra 77&31 6.oo 2 P--eepariiis it!frorcd . 5.4i Book 786'10 78689 4.39 Book 79170 2 8.93 JE 781 59.@ 50 Pho-$Iocopy Si-7-50 l@ise. SUDDlies 793514 7.12 2 S,--Nqs, Ea-w'--,!-,arpened torl7 i-1.64 Re,prin;ls 33-90 l@,31d release 5.84 office supplies 8.80 33-63 li@@,q service 82-25 II-alti-lit'n2 I;j pi'De 2.42 Book 6i76i. 5.34 Si-0-26 20.34 2 P'n.,irr,z-ceu,L,ical supplies 82487 37.29 -i--Icc'-,rodes, po-@,assixx,3 hyd--oxi n 82v-23 2 3.0.40 "prin't's 35.6o C"I(--,aicals 82853 Graph sl)ect'Is 63304 9.57 Book 2 83425 20-39 F:-eiL,h'%, 639,06 9.94 i.Ilus'ura'@i-ons 'Tt--io-8-2. 6.oo 2 E:,' 2 13-91 13.92 C'! C:.- 1 s 52-53 Fi l-@er @,nderser t@)d f itt-t.',Cs C55575 2 g.oo 1.;cdic--l illustra'ions Jr,-11-52 :L6.oo 19-57 C- 1 C 2 1-1.51. SJ-12--ig 6751-6 3.62 "ISC. SUP',)Iics i@@- dir,-,ancc 2 SJ-12-74 2-30 46-30 8,-@170 12-36 (co:-,ti-ruccl 5 on IzZ@o 2) 2) VO. 140. 32-09 Reprints2 SJ-1-82 18.20 supplies 1.&5 91227 supplies 2 :to.67 R4@.Drints 91531 6,73 C@Dr,@er tubing si-2-64 2 76.5o i-31ust@rations T.:-o cnimi@c-nzees Si-2-42 300,00 SJ-2-79 53-75 1.90-- Si-2-48 I.ONG d.is-iz-rjce @-le-Lei@nole 2 10-50 92323 Vise. istt-plies 102914 3@0-82 2 61i.40 plu-s, recep-L'acles 92939 22. clic-lili-c,,Is 2 92989 R--'Lb i t s 93105 51.50 lee 93217 19-78 Fhoto supdlies 93592 2 73-93 ii-lus'@r,-tions JE-3-43 '(7.25 T,onE, a;-s'-nLnce '@elei@none SJ-3-62 14.45 2 supplies si-3-6), 63-21 2-4-15 1!.i-sc. Supplies 93919 2 63-91 s 94055 7'1 - 25 -co i t s 3.3-57 2 Fc,:,arin,lZk 94132 - 13-34 '-k'cyor'%, cards 94384 Ice 94394@ Po.62 2 C'nc@nicals VIOL>-.' iy6 58 ,nk4h8 5:57 Bs-r w 2 8.61. C'ri.x-onosorb 9)i);L.9 7.67 r,cedler, 945di C.,ici-.icals 9114559 2 15-06 9.69 Cr-@ph paper 95033 16.99 Plexic@LOS 2 9504-5 Pc,blic--ti-on 95169 2.49 iiisc. supplies 95167 6.oo ita7b'oit pc3-lets 2 95pol 34.i8 R@,-'Uoits 95217 25-75 29.,6 "ni--2tl food 95381 95437 -.5-39 si-4-6i 4 -72 Ar4=al2 feeders si-4-67 38-47 Si-h-r @ h.65 i,ong distance clepl-ione 114 2 lrn.!@.r,@accutical SUDDlies si-4-69 7.42 Ice @C583'1 21.91 S@-@ in f-,c s 2 o5676 10-30 I 4..24 95923 bl,,,des suonlies 7 (@15992 3-00 20.19 jar 9'aooo co t-@'to 0 VO%l 1101,181 CO, c@ (A C6 c@ C5 4 ci r) 'Cl@, 2 0, cr% CN o,% U) tn 0 (U r 00 0) 4.4 5 0 EMORY UNIVERSITY 22. GEC>JTGIA March 28, 19'00 4OFFiCE OF T141E C)IRICTOJK DIVISION OF E)ASIR- tiEA;-TH SCIENCES iq.A 2 Wow A Dea r Attached you will find our research proposal for the year 19'40-196). We hope your revie--.,iong board will look fSVbi@bbly,on this applicationg if th(-- grant can be activated as of June 1, 1950, we shall be able -to order certain items of2 equipnent and thus decrease the delay which nay result in clianging our laboratories. I shall basin i.;ork in- hew - e@ 1, I 0"0- If you -or the off i cers of the jersoy --s of July c@@ Fave any questions, I shal I be glad_2to appear before your group to-explain or justify any of the budgetary itens or expand on the detai Is oil the pro;>osad research.- We are -roceeding with the testing of the-codpounds which-%" has s ubn, i t ted. Yours siiicetelyy 4 Carl C. Pfe CCP.cw EMORY U141VERSI-fy EMQRY UIQIVERSITY. GEORGIA, November 20, 1959 Orf#C t (>f TM f C)IRECTOR DIVISION OF BASIC tiEAL" SCIENCES Dear 2 red on November 18o Attached you will find a copy of-our budget report prepa n cted for-the grant u til june lj, )960. From brances proje 1959 with en nt from thttv, ta:lzet 4 11 note that-that the gra the report you wi schedule and will be used up as of iune is being spent according to 1960. date, but a quarterly payment Payments are co-gpl&t-i@--as2 Of the-present will be due Emory University on December-1, 19-59.--- te;@--144-report for the first six Enclosed you w i I I f i n d lalmDo"v!@@ -ih---Atianta-Penitentiary wi II be - months. Our report of d2rug testin"t c sent to you early in DeceiTiber.---- Yours sincetely, c I" Carl CCP:cw cc: Bur)(JET RFPORT 3 As OF., tiovernber 18, 1959 TOTAL AL-,OIJNT Fky'riENTS 2 13!kthNC-F' ACO)LINT (Total 7-ncumbrance) 9129-03 1.,006. 2o.,994.. I2.,006, PERSONNEL 22,000. 9129-11 20. 2P. 5, ? 5,500- FE LLUIS li I PS 9129-15 2 2,809. VOLUNTEER 4,500. 1,691. 2.,609. 326. 9)29-24 814. 3z6. TRAVEL 2 I.,200. 9129-25 EQUIPMENT 8,590. 67- 8,523. 61912. 11600. 9129-31 2.,Ooo. 4oo. IJ600. SUPPLIES 4 $43;540- @29,526. $14,oi4. $1,61). $12,403- R-:MORY UNIVERSITY FMORY U@-41VERSIrY. C-EORGIA office oiF THE C0,14TROLLER October 5, 1959 Gentle-men: 'We enclose the Or2i6inal And one copy of our report of receipts end expenditures in co-,.nee@%lion vit'h the Gmnt to F,,iory Universi'Ly, -unler the direction of Dr. Carl C. Pfeiffer for the perio-I tune i, 1958 throu_;;h 1.>-y 31,-21959-- KindLy inform us if this report is not satisfactory,. Very truly yovirs, F,,-'Ipbt C.- Davis Chief Acco,.intL,-vit RCD:dp\- 3 F,ncls- CC., Dr. C. C@.--Ffeiffer F@@@rt!nent of Carl C. Pfeiffer Dir,@ot SiLi,,.--Ary of Receipts and Fxpendi,4,ures for LP@t-@l 2@8 the t)eriod d 5-IL-58 2.,i56-98 Balance on ban 48 2o2.oO Received from-Gescbier.-ter Fun,d :L958-59 Direct F-%pctn2ditu-res: 24.,880.12 rersoaqel 7,200.00. Fel-lowsbi-PS 2-,GI8.00 Hu:-,P-a Subjects -a 2 707.01 Travel ------9j7O3.39 ]Equipment 2L lk8. FApen&--ble Si@,Dplies 2 i22 Total Direct FX7Penai'vres .18 YL - Cor Lribution A-0 Indirect Cost Total F-Kpenditures- - - $_5j.465.00 2 ,@b@(" $ 0-feraraft P-S-OF 5-31-59 (To be elbsorbed by Y-@ORY Uni%;ersity) over&raft See p_t-ei- 2eci scledxiles -h EJDRY UNM-RSIW APPBOVED: e 5,1, C.4 c@@ri-c-. i@tafftiii 14. D. chi,of iccoLiLnte-nt pro3ject Director e3 pc r,!2-Au: c Li FI@X)RY t)IiIVERSl@lry ent of rnar!,;f-cc@io,@ De i-)a r rTh- 2 Dr. Carl C. Pfeiffer Dil@@c@tor losi'-Ion A.TLount Rese,-rcb Professor 2,400.00 2 Secretary Research Assistp-nt 3,975-00 Assistant Professor 7,916. 6) Instructor 300-00 2 75-00 Research Assistp-nt 1,200.00 Researcb Technicia@a 6c)b. oo A5sist,,nt Professor 225.00 2 Consultant 2 -5 .So@ .00 Visi'in- Associate Professor 2iloo.00 S",U(,Iellt ss2is n 526.50 S'L.Liclent Assi-,,,;'Vant - 1,4'9rl-75 S'tluc-le.-it Assistr-Lnt 765-85 S o C i a I - S e-c--o2 --r 1 t Y- 3&[.,26 Atiniiity-Di.- i-ii6 Total Fellow- 300-00 2 Fellow 3CO-W Fellow 3,300-00 Fellow -.31 3 9 q @. 0-0 Total Fellows-nips 6 7,200-00 0 lie &W Date:@ 37 F,14-)RY UNIWRSITY De-oar.;rien'-of Pharriacolo 'eiffer, Director C. P-IL Date Dzstination CK.NO. Amou-nt 9/16-18/58 Dr. Carl C, Pfeiff6r--Frince'L.On,-Ni@@-J. 62cyl7 130-84 .20 66569 12/2-3/58 2 6 73910 17 -32 4/12-17/59 7391L> i.80.00 4/14-17/59 2.6 1 8J 41 2-2 142 )i/i2-i8/59 Total Ii'ravel ex,,' Date$. YJ,DRY uiPM.SITY E6--,Lart!-,entof@.Ph,,rr@@c 0 Dr.,Carl C. Pfei..fer, Director ITEM Frei&bt. 2 5-73 Hot Plates 6i.8o Elecltlri.c Clock 10.82 FreiGht 5-43 aj-D.-tm-os'er recorder 776.278 Crtr'%Ion 'O'ffi.ce l.@'Achinery 29.10 Freient: 20.50 Aero&raph with accessories- 827.86 Frei6ht 2 29-43 16.54 Frel.Ebt Electroencepra-lo@,raph-,with accessories 6j242.83 I,le-tp-l Ce-binet h.ig Sey-vi2ce cnar&e 25.00 Semi-micro liolarimeter '#-,ube 30-90 91.67 Inte&rateux Blectronique S@-,ientifie App!-ratus- 312-39 InterExe6.ter for-Blectrorie,-jlialo,@;i-aph FreiEbt total Equile.-,ent 7 UtM t t 0 d C El-f)RY Lailv-BRSITY Del),@-rtmerit of pI--Iari-acol,o&y Dr. Carl C. Pfeiffer.- irector 2 Pd@DtJ@4T ITEM. Al.DViciT 'Ls C b cyr i- cAl s -a- $ 11-33 Ch2o-mi-c 62.71 .65 liire ii.80 Pnoto -lab* vork 7 2 6.og Bulbs 9-27 6. oc) Dry ice 8.32 Ca'Us- Doi,s 18.oo@ C'neni-CAIS 15.20 27 --- Office-supplies 8.20, Frel.Cnt 2 Che:ni-cals 1-38 Filter s'Llri-ps, pipe-Ltes 33-17 Ca@L's & PostaSe 0.66 Celi@'le 2 7.73 Supplies 37-91 An food 39-14 Che-@@-icals 25-39 Che-miep..Is 20.19- ----Che@-@iml2s -10-30 Telep@i)one bi-U 2.48---- Dry-ice 22.54 I-lisc. le-b. supplies 10-42-- 2 10.50 Tubes - 62. 0 Bulbs 6.i,8 1.,'ain't,criarice supplies 20.38 Rp-bbitt@ 24.72 2 Telep-.oone bill 6-33 chp-rt -47 c -20 I.Ilisc. lab. suDD-lies 2 18-38 I-II re ho.ih 1.11:sc. lab. supplies 8 ' 50 i-n@Llerkknt6 - suoplies 4-52 F,Iec'-@rodes & wire hi-94- 2 36.oo Yeast 4.04- IP',-)ai-c@accutica'L- supplies .48 Hydrocen sulfi-de LL@@@iiia.'..ed albunin 2 3-33 i-8 44 pi-i6 yi&t, -, -- -- - - i , -4:94 0:00 2 subp-.ies 1. l,ritared spectras 11.59 Cats 37-00 Dry-ice 2 15-33- Bin(ii-ng of Joii-rr..%,Is 31-05 Tri-frased spee'tras 9. (V )-lice 36.70 Hea-ritz flid cares 8.14 Plip-i-rp-ceti@lical supplies 7-00 .17-37 Cats 10.00 Book 2 35-06 Tubes 12.U Book h-78 CI)e:,-ica-Is 55-86 36-50 Reii@rints 2 24.io Tel.eGra-vu 3.00 Ch@ @ i c P---L s 37.56 Publiching-cos'vs 33 6o Dry ice 25.4o Chcz@icals 8:29 Ce-'@s -i6.oo Book 7.6,i .kni-,-,al food 68.5o Dry ice---- 2 33-98 C"-)e:ni-cal-s 12.91 D,.) r, s 27-00 Dry ice 20.4.9 Pha--r-iceuticol E;upplies i.ki Ca'2@s 25.00 R--bbits 41'. P-0 el eplio:-,e bill 4..62 Rer-,r-'-n'us 19.32 B..-)Olz 2 I)-.V4 - - - I-eddl.e ve-Axie 14.,Ig @.7--I,e dispensers 6.86 l@lais 21,,63 Cats & I'"-sc. lab. s-,;cplics2 26.%, Misc. supplies C "-) e::. i- C P- I s 3.76 C@iezicels 5,-.>ok 5-39 Slide rule 6.13 Book 2 17-32 IA----p & cor-nectors 28. I'[ ce Tnemo::e-ers Con-'.i.n-jed t-kxt- Ebi----TVX 8 Co--i'.iriucd '.o lp-t-e 2 Dz, e g n.lory tnilVF.RSIfff 37 r T--;,- Co 1 0 E y @r. Director PJDUNT 2 25 Dade -75 1.1,:sc. lab. supplies 8.36 Reprints 35-)18 i,6.42 D,cy i-ce 16 32 Ch2@- -ubi.ng .-icp-'Ls -t l@2:96 rr.p-ceutical supplies Books 37-28 Che@-- i ep-I s 6-59 1.',715c. supplies 2 .86 chp-rc,,,es 5-49 Reprints 26.47 Book 13-17- - F,Iec'@fon tubes 31-13 A-nii.@^l food lo 18@@ Fr2Iotorraph 3@'-IDO- ,ic service Telel@'.hone bill 4.70 36.8i sei-kice 3 -5-0- TO@ai 9 C! x;. f RECEIPT llo,,,ing two chec'ks#. wiedged Df the fo Reqcipt is hereby ackno teniber 19591 dr-1'9'a On f2ficial Check No. G3557Z, dated 3 Sep 0 in the amount Of *'Wow, 8 00, pa' able to $48,37 0, Check N67@7UT 54860 dated 3 September 195@9.@drawn5@oa@ Caihier in the amount of 4: Date'. 24 Augustl959 ).iFMORANDU)A FOR.$- CP.IE'F'o FINANCE DIVISION VIA TSS/Biidget Offlttt SUBJECT ),IKULTRA. Subproject 47, layolce #10 Allotrneat 9.Z50Z-75-9021 1. Involce 110,coveriog the aoove sub,?roject II attached@- Pitynicat abould be made as follow-a,. 'f$48.378.00 draws% Cashier's check In the arnount 0 Cashier's c-hockl-n--the-4@@nt-of $1.9)5-*IZ,drawi% payabla to rach check should be 2. Pletee forward the check to Chief. TSS/Cbt@ffitcal Division through TSS/13udget Cfflcer by 4 Seprtiiiber 195,9. 23- This Is a firal Invoice. floweyer. since It to anticipated that addi@onal' funds -Will be obligated for ibis project, the file# - shoold not be closed.--- Chief TSS/Chcnllcal ])Ivlsloa Att-achment: Ir,yolce & Certincations- I)Iiitributton: Orlg & Z kddresses I TS-S/FASB TSS/CD TSS/CD/. INVOICE $50,313.IZ For services ............... . . . . . . . . . . . . . . . . . . . . . . . . . 2CERTIFICATIONS JIO applying to Sobw (1) it Is hereby certified that this Is Invoice to satlifacto@ry, that services project 47 of MKUJTRA, that perfotii-iance i - 2 lthiiiutual agreeme are being accon-iplished in accorctance w nts,, that a@ entg and receipts Ia ile In TSSICD,, that -on r "detailed agend2a of the PaY"n just and correct and that pay-inent thereof b3g not yet-been thi II bill I 0 made. -fss/chelnical-Dlvis Oa Date:. 2 is invoice applies to Sub roject (Z) it Is hereby certified that th p at the project No. 47 of MKULTRA which %vas duly approved, and th -titmoranduji-, of 13 April 1953 3 Is being carried out In accordance with the r n th en ton t this authority In subsequent frorn the DCI to the DDIA-,- a d ---kcsearch Director Date: July ig I ME410-lu-NDUM FOR-.--CMOs llf$Anco Vtsj@OU =C liKU1,TRA,@ SUb-proj"t 4749 ItreoiCe'll;. 14 -1390-2390z-- otm@ cAt ZIZ5 roject is atfti.-hea. - ccrvorInZ the abcrrd &-U!>P Plymeat isho@dd bo tnado Xs Casi@'er a cbetk In the am2c,,Imt of @30'740.00 4 A@ 4 A t vtt-i' 229. 60 di-awn oq C h t i@ crA cl b,* -znapayab I o t 0 t b 0 Piezz e farw s to ChLie ,T by z4 itay i?6L Yevorm of co it la w-Ati ip tt-@d aL't' Itional ltmdj v4U b43-e.>Ii@;44-d for tMs proj"t --tho fil r-ot b IVA 2 IA t,,m chod.- HEC -C 7Y -.t!CUiNT (IF. Cor 40. TSD/FASS 2 TSDIR]3 E P- 7 -t\l T ."TS D/RB gap 1 17, ix z C P T bf tb4 folloving'- ereby IsZov e el 2 - TUIY -1959, attwil iclal.cb--ck',Fo..9,33737x kat&d- the S-fnount7 Of t-he 24@@O 2;134,67.. jaye:ble to i959 drava (>a 3 in the amoud t (if 0,-rl-i c I al Cbeok rio 6 dated 2 July to the -Dat-^: ...ZX INA44CF. IVLSIO T SD BUdge't Officez, bproje liKULTRKs -Su et 47 lqvclce #11--" '052 94902 t -5-100 2 Ice fit coy,*,rlng tiieabov@'lint@project PaymenLt should b do afollovrs I !4 O- i $49 c4lhler's'ibeck ta the tinount-o .498- 00 0 2 dra%yn on W--no L &C h c@tck should be' rna 2.-@ Please forWArd tb'e cbec@,s to Chiefs TSD/Rtgcarch-Bf"th. -et C OfG,-er by 13 July 1960. 3. This is a final Iiivoice. projecttc 7 t addltlon;tl -fueds -Wlll be obligatod [6"his ould not /g, A*@C C I V F- 2 D/ReacLarch ]3ranch At2tachment,. Invoice &C Certifle JU tlbution: -1 ilk.-IrY IliAT FV'@VS -,@LIE AVAgA!f Addttis' fig Z co D/kASS -@T .65 TSD/ R13 ci,,Ikcf2 l,'H E Or, -,Jt'@ j. E@ -,%a,.Icj u R E 0 C-. I V E-: Or, .;ZA Cost Acc@ount Object Class bligat)o@s Oblig6ations 0 Date Revj)arks and R(,fcrcncOs TDCUITed Liquidated 22JUN 1960 ij9U6LO Cost Account Object C)ass Obligatioris Unliquidated Obligat'@orLi 6 Remarks and References Liquidated ]Balance Date incurfed JUL 9 -195 OCT 22 Z5 Juno 1959 mFmoRANDUM FoRt CO)-IPTROI,I-JUA ATTIENTION DlvlDloi3 SUBJECT I.IKUI.TRA, Sul>project 47, kdditton&l Aut2horization No. I Under the authority granted In the inemorandtim d&te4 13 Aprll 1953 from the JDCI to tha J)DIA, agd the-e-x-ti@-@@s authority la subsequeat-i@iiemoranda, Subproject 47 has been approve4 and $SO, 313-.IZ of the- i@@--all ?-IKULTRA project-funds has been obligated to cover the ou'bproject,expcnoe#. This o'bltgatton of 1-i-nds shou-Id bi--i@hara-ed to Allotment 9-Z502.75.902. 2 Chief TSS/Chtrnical Division APPROYYD FOR-ODI@l'%--IATION OF FUNDS 'URTIFY Ti4AT FL!NIDS C"k LE 10 2 yot .Research,[)Irector- Date: 3 0 ju/; Dlatributlont Orig tc Z - Addresses I/ TSS/OC -@-I - TSSIFASB1 Z - TSS/CD - ' 1-i 4 - (Who,, Ili 4 j Ali In) CONFIDENTIAL FL%DS POSTING VOUCHER NO. 7.42 OArc Z.$ VOUCHCR 40. 7-11 vou A3 -44 5 47 6 71-60 2 34-39 4-70 F oesc*IPTION-AL%. OTHER ACCOUNT$ I'S-S3 40. a 0 @53 AK.LOT. 0* COST OUC AMQU14T 2 PAY II EFt .4. Accy. No. CATE :OD, C.11.0 ".ERAI. OESCRIPTIOOO- oc PC" . .......... ICA LEOGER 62. 2 ' ;: : '. ' CO 441c"r@, l'o, AQYANCE ACCOUNYS, ....... @ll AICI. No. CLASS FV Cooe 0. OK, 2 EXPLANATION OF ENTRY 'ROTALS CERTIFIED FOR PAY@MENT 00 C 2 RED IT oktr, PREPAREO BY @OATE kcvlcweo Sy OAT.E .@,@S I GNATUR E 8 FORM (10-40) 6.59 606 use raiivi*Vs go$Ti*Ng. .24 Augu6tl95 ISI 4N .3ArMoRkNL)UM E'INANCE; DIV 0 TSS/Budget Officer L ;-2 SUD Cl% ).IKUITRA oj 2i@@4 7Invot cI 0 .9oz ..@.-,Allotrnent 9.25OZO75, voice #10 @c@@trlng the above sub2r-ojact' x' ttached. a -"-follows:. ti o;xld be m do 2 n k@o rinount...:.. --!Ps@be.ck Ih-P of $4-$,378. OCP* hf' h-c3@ 1-'t d.ra. -Ca era c a no itthount Qf $I# ach che@k sh'o'Uld b o m4do 2p-aya % Ploaee forwa d the chock to Chief TSS/Cb4tTnic&l Dlyision th-i'ough TSS/13udZet Officer by 4 Septernber 1959 )'*-'This Is a fin-al7fdOide, llowev6r'. pince It Is Anticip funds-,wiu be obligatea [or t@is ojoct, tho file$ ihould not be close.(I@. - heMIC41 r 41. Car C? 0 I)Istribut-ion-. Orli A@dr4a i'b a a Lp. D 7475 L/ DRAFT*4vl iq 25 June 1959 MEMORANDUM FOR: THE RECORD - SUBJECT l@,IKULTRA, Subproject 47 2 ovide funds for 1. The"' rpose of this subproject is to pr .@>U the continuat ion of the prograi-ii being carried out at Fmory Univer_- - sity under Carl C@7P'Leiffer,- M. D. The scope of this Nvork basically 2 covers the de-v-elo ment7"d testing of new chemical compounds which are hallucinogenic--or otherwise affect the central nervous system of hurnans. Certain ph@@-of other-problen-is of interest to TSS/C.D will be investigated. Z. 'fhe nature of the investigations to be carried out under the 2 direction of Dr. Pfeiffer encompasses the synthesis, pharui)acology and pertinent bioch-ii@istry of potentia) hallacinogenic chemica com- pounds. Testing and evaluation will b-e conducted in normal huinan voltinteers.- 3. The ftinds for this roject will be ti-ansferred using the 2 7@-@;was a-cut-otit; 4. The cost of this program for a period of one year beginning I June 1959 %vill not- exceed $4'-" 378. 00. To this suiii must be added Do aeca to by a- 1'37 5 e.it0e ii@ne E2-11 7475 7475 b, $1,935.IZ reoresentincf a 41 0service charge to nt 5 0, 313. 1 Z. it,-aking the total amou bould be made against Allot-2ment 9-Z50Z-75-90Z. Charges s has request d Eimory University 5. to submit to th@in a suiiiniary accounting on aq annual basis of all iiionies received from the Also, it has been requested that any uccxpendcd funds be returned as soon as possible upon the close of the grant year. 6. The requirement for a six i-i-ionthel informal accounting on the part of the principal inv-estigator is waived. 7. Title to any erinanent equipment purchased by funds granted the University shall be retained by the University in lieu 2 of higli overhead rates. 8. In connection with travel under this project, it is agreed that the Agency will-accept ttv67trav-el-docun-ieptation and accounting which conform with the practices of the University. 9. It is agreed that technical reports reflecting the progress of the research progra5m shall be subroitteti at i-nutuall.y acceptable intervals. a to. by e@.ith ity 0,7. 187 4-75 8 5 Do,.,, nE, c-d to by au -i@i-i t I -3 - E2 !.'?D 10. Dr Pfeiffer has signed the Menioratidum of Agree- rnent and holds a TOP SECRET Agency Security Approval. Chief 2 TSS/Chei-nical Division A13PROVF@D FOR OBI,IGATION---- OF FUI\IDS.. sear Date: (o Atta'chrnent: Budget Distri2bution: Original only ed to: t! ty cut ority c une e3te: 7475 PROPOSED RESEARCH BUDGET June I i,959 to my 31, 1960 for Grant to Fnory tiniversity by the PROJ-ECF A. The synthesis and drug enz),wology of possible hall I enic cheiDical6.--- @c, n 40 flersonne lit $8300.00 4380.00 2 USPHS Gratit Equipment---- 2000.00 Travel 500.00 Co nsumable Supplies 2500.00 $17,680.00 2 Tndirect cost - 10% 1.768.00 $19,448.00 &"@ROJECT B. The Testing In norinal bitman volunteers and the-- pharmacoloi,,y of@6xperimental-ballucinogens. 2 Carl C. Ffeiff,6f,--Fh.D.N.D-@@riinciple Tnvestigator Personnel cAa5l, C. Pfeiffer, Ph.D.H.P., -(pA-rt--time) $3000.00 3000.00 2 3000.00 St IPA.!IA 3000.00 I -4. f or-.htmnan-)i--olunteers SuTm-Der Student Fell(Aws (3 at _t6OO each) 1800.00 4900.00 500.00 Equipmeftt 4000.00 C<)nsumable Supplies 2 3000.00 Travel 1000.00 $26,300.00 Indirect cost - 10% 2.6'30.00 0 8s930.00 Total of both projects - $48,378.00 WARr\1114G E SOU,ZCES At@D@f.',ET IBDS It,.' OLVEO PROPOSED RESEARCH BUDGET Personnel, i@cluding volunteers $30,980.00 Supplies and inateriel 11, 500. 00 Travel 1, 500.00 43, 980. 00 6 Indirect Cost 4. 398. 00 Total $48.378.00 Ca,rl C. Pfeiffer Ni TI SIT V NT L SOURC NVOL @cD 74 XT -4m?;u Dimictl - -10-001 'I @,a t 2 -lest@-.d that ya It is re @cR@ bev a BO fO dmva Ca camier's ch@et In the Oa a bu* 2 L@ iQu34 mu'-o Ia)-ab 2@o th by Mday, 10 July .1959.t it to anttclyixtod fi nal -voibe Hc&-)vor2, @ince pi-III a '6&Utlc,--&l fMs vl 11 te obli on@oi f or tble proj"t'- th^, "s mt Chief atcal Divi 0 I' 2 Y THAT -AtE AVAYL 0 Invoic-0 Certi-ficatloas Distributloat (:@L-IZ& 2 tar 7 r up --T I moics $33,h-'->0.06 ----- - -- - - ---------------------------- CERTMCATXCM (1) it is hem-by '@18 18 2 InVOICe 19 applying to SA @erti-fiC-d t'@,fAt t. 1-irtcelo ect 47 or V..am.TKko that lvrforic,..nCA3 Is O,@Ltiefacwry"o tbat-t4 am 1-@eirkg aecoc3plAO-,ed-in accordpnce vith uitaial 6&mec3entap that detalle@i ae-,DU of -tbe-lAy@4ats _*xA_rec7L-Ipts Is on fi,le'in @SS/CDF tia2t this bi3LI iis just coi-i@v,-ct t'@-%t yaynent the-r'L-Of has -iDot-ytt- beea DIV16IC-a Da f@,e I (2 It is hereby c-@-rtifLie4 2 ppl-ice to Ou'b,,pr\>Ject No! 41 of V@,1-ILT.Rk-vlb-tch -*,,%s duly-appravc--d tt-lat t@4 pi"-ljcct-to e@cirrlod 4Dut In of- 13 A,-@rl 1. - 1953 --i'i-6cta the LICI tlo tile-to/Aj In sub,@-oVMV@_ rm- a t-e 9 'Z ofh 7 .45 CO@NF!DENTIAL FUN@DS PO2S7@,@'S YO@'C,4ER VOUCAEPI 110 . 71 2 VOUCH(" NO. 7- 1 2 OESCRIPTION-ALL, O?WER -ACCOUNYS 13-33 34-39 40-42 5-46 2 4 a- 710 - ZS- 33 STATION EXPEND PAY OBLIG. So- 57 1 ALLOY. LEDGER DUE 71-oO COOE PAL ACCT. No. OA 2 We ...... CODE 1r6f4. it 0 9 SC It I P T 1 014 A 0 VAN C CACCOJ)NYS 13- FUR P. No. LEDGER C .1 GI 11 11 AMOUNT 2 27 i..O. Accv. No. %CCT. No. ............ VA 00.IECT :j 32:@ 7 2 - DC IT 'ovICODC a I v. mcr. no. CLASS @44 94: @4@ 4@ 441 t I 2 rj T.ANATION OF EN TRY TOTAL$ DATE By DATE irevicwco by 2 CERTIFIED FOR PAYMENT OR CREDIT OATC OF. c@r"TAI foam o" 606 v I 9 P 4 9 v I *us colviono. 5-3 e@--ri C. P.-e j'Lffe-r Dlr%-c!ar. - ReceAe.-O WA for ths n,(-riod B&I-A.-40 on ht,2-ra @-31.-,c8 2i 156-98 @S, 2c,>.Oc) 2-00,00 'o 2 78600 Travel 7VI-4 9j7O3.39 Cor-st-r-4.bl.x'vioa to Cost Y18-18 Ove--dratt, " of 5-31-5@- -(-,a be eb--,orbe44 by Y-z@@17 U.-dv-ert ity) Dr,, C-p-rl C, Pfelfferi -No D. t-ki P-h-c- Di r,x-ojtc-t Dit-"-tor Aco@o@tant nit of nr=-s-colo 'U- tor Dr@ C&r-l Co - Ffe Uw. oo 2 3,, Y7 5 00 7il9i6l(-o rrob,csoor 3 2 lnztract-or cl- 75-00 I eoo.oo 600.00 2 k55i6t,"t profcacor 225.00 2)025,00 Conrultant-- 'Visitil,@s Prc":,Ci 21100.00 ,26050 1,,497,75 _@b aoc),Oo 300.00 3,300-CO d abe examinea and app:,@--; 1 ex-penditurcs- C t.@ 1 e'f Date:@ 421 c@l :Ir co- "HY t c @-7 5-73 ilreigbt 6i.80 2 y,,It Flat-es .10.82 F-leotric Clc'4-k rrcight Ti j>ir@p-,.oster recorder lo 2 29. OffIC-e 20.@O M*66 FrelFht Ties - ------ ,O&Ml)h vith eLCcessO 29.h3 Aer 3.6.54 t 6o242-83 y,lectj,,ocDce,pralo&rakh vith aceec 4119 IL@tial CeLbinet--. - ...... . 25,00 charge 30-90 91-67 cl@nel-mistmk Teletb I..,"P-ateur Nltctroni- O.t-- 2-0", -Tt InV-ri@i-ater for nt 8 -.,A7 P-nd ex;; 41 "RY MirvTRSIT)f 0 4-1 2 -d Dc-,-c--rtji@@-nt of PhAh@@lo&Z Dr. C-ri C. Pf@ciffer 2 j_Direet@or iT 33 its Photo ],&bk vork ;$ FLL-E iFIit 67 65 W .ilrbe 8.27 C@ats 6: co*" Dry- tee 2 032 D:@Fs 18,,00 Ch&Awle k 3.5., N Fre t@&ht .54, OffiCe SILDDII-ES --'.0 +:33- 8.26 Ch---dcau okeepinz v*applteaj 1 38 > i; - 17 Cate Al Fos ot Filt,er vtripep pil.,-%tt-es 336 a 9:66 rupp x 0 Cel-2it4 7 *73 @A 37 A- Anirnl food 39oLu. ch-o@-,Imis 23.39 - Cbc--,.Acals Po 2 CilMiCCLIS 10:90 1-tleleiZo-3-i bila 2:@ D.-7 -.lee ;22 1.!Ieco la73# &applies 30142 - OL,-ts 10:50 62,30 Dilbs 6 i8 PO-38 Be@b%its e4.72 2 bill 6-33 --Cla-rt nc.ctroacs & vh-a 41.94- Do&s- 36.oo ymst 4104 W-1-OF,e-I 6--dtid* 3-33 2,i.i6 );I"tric sipplles- 9,00 Dook infare4 cooc&%,Ms C-ate 2 37000- Dry S co 15-33 - Ain;iir,s of 'FxuTwils 31 oO5 Infi atc-4, @@ras 9000 @tice 36-70 2Hci@irizz aid cares na"c,cutic&l C,'.IPPlies 7 00 ra%ubixid & v&re 1-37 C@-, t 3 iooo--roo Tul).-, 2 12611i.@r-00 4-78 Chr---Ac!Lls 5 086 Cats 36.@o P,o,prIL-te 2.1010 W-le 3,00 C'L)(---JCAIS 370@ Publichinz --w s 33-60 Di-y lc4 25, chc--I"-Is 2 6 29 Cits 16.oo --DOOV777-@- 7:61 Anir-@ii f(>A 68.@* Th-y see 33-98 Cb2,e:iicau 12 D6tt-7 27400 pi-Y ice PO:477 n@bw@tioal oup,-a-I e s 1.41 C-St$ 2 -@o r_ , 00 F.!@bb i t-s hi.,.,o biu c(io,62 -- FcpriiAs 1?-32 Book NCIAdu vaiua 1 -79 7ar,e 6.06 W&" C-ate & Ydsc,, labe i@upplies --1,16 54 -- Xie4 o)ipplies 3:'2(6 5039 SI-lAe I-ule 6.lj r.<>Ok .17,,32 A 66ii@ic-ct@ors 2p;.il )ace 7 13.6 C<)O-tia-lad. ;o loze 2 Carl-! Pfeiffer,, R16co, lab# Ptpplies ih-.f lea ii 42 M-iloAl-ar tubing i6.32 12 96 26 *4i BOO% 13 -IT El0"tioa tubes 31. AP-t-Al lools OD bill 4,, o Total Dater NA-' owing: R ceipt Is hcre y awn 1958 heck No.- the amount Of d a t c d Au gu n t 2 dr -ev6 -Triaturer's C On th e yable tO tE-e $6,4Z.69. pa' Re 5@8, drawn --dated-Augu9lt 6 in the amount Of k, ofr offic $i6 7. 3i payabl 067.3 -DATE" 7@ v ')k Ake-. 16 v July IVA 2 @7 C -C, DLV'MCU If 7- Ifo 47, rrr.,-Oi Oa tn2ent- 6-25W--10--001 1-; lwoice ifo@i-8 the a-bave- a ------ - - -- It Is re(l@i3stcd that paywut2 I;s C "-h i'e r' ebock i t@ie anolunt ot $16.,067-33i drW4n on a C iz@hteri.@ id--the ezu;A-mt ct .69, d re-. a 2 or_ FA.--,b eU cL- abctild bt,- t4aM- to 2. &.o&a thoom ba-f6i@@@-t6@Chle-f CAI Div.1 t OMeer., 14ter thqn Welnesday., 13 AU@,vat 1958 Divio!on A t t-o@en t-3 I Invol,,,oa WA C ortifieatlcca Z L; Ii t- (i I - iAt!i L; U 14T. C) A-tic Dlptributiont v,"'Or I gb 2 -Addm ir 4z It is @,izN.,by corti:rie.A tl,, a lw thu is Lnoice Voo 2 a 'Lpplyirg -to %IV -,V.IO- @,% Ct 4,1 of that performnee lz-satiefictory.. tli@t o,--a a4ccpg@@@@ord-"Oo vith iautu@%x a&i2w- Js co pay=nt3 atd re-@.@ t la.Nwat -SIL-1@, that t,-,1!3 bill 2 i,-l j@st L am tfli' '@at this lavoice appues t@o Subprojft c*rtitte4 L Xt'ls M@ew, cc ricuLT?.k Which w-9 diily 2z@p-.oroved, " that t.@e-pmj-2et :L a be in& ed mt in fi,@.c@ordancA.% vith tl,-,-, re.-*rwAun dattd 13 ,IrZJI 1953 t-"t to tLa DD/Al ard..the exteivalon of this authorjty in 1 sub,@. 1) ctor Jr D C tTiAl 7475 IE'Z I DRAST 19 June 1938 MMORAN" FOR; THE RI)CORD SLMSWT YALTRA,, Subi@foj2d@dt- 47 -76@ji@dt it--to, provide funds 1. The puitose of-.this for the continuation of-the-program being carried out at Emory-- University under Dr@-Carl C@7Pfeiffer* -The ti@ope of this vork is outlined In t2he attached osal subaitted to Drs. Pfeiffer-- and 0~ and basically covers the develOXeu@ testing of r-ew ballu--,inogenic epm@ds as well as certain phases of other- problem-s of interest to TSS/CD. 2. It should be noted--that " in past2 -years,, a -consider- - able portion of the total -cost of tht--IndiitAted progrem,@dll be borne by agencies other than TSS/CD-. -These' include the U.S.- Public Health Service, -Emorv University, id otbers. 3. The funds for this prpject win be tr2ansferred using the 1112 $'BOA as cutout in the usual w-nner. The cost of this program for a period of one )-ear, be- ginning June 1958 vil-l-not-6Xce-&4- W,202.00, to vbicb must be- 2 a-d4ed tie folir percent (4%) fee to the EQO, i ng the to'.al elmount $50,130-06. Chare.3 sbotod be mde against --- Allotwnt 8-2502-10-001. bas re The quested Emor-y 1University to dod by -ali f..: 18'7475 C- n t L, Li n 7 K@2 479 t ut ity ofo. E2 11 L UBy an annual basi inting on @s of al-I monies received from the Y\tn(l- Also,-it.has been requi-sted that any unex of the 2 pend.ed be returned as soon as possible upon the Close grant @,ear. The requirewnt for SIX mofiths' il]fol-mal acccklnt'ng on the part of the principctl-investigator-is vaived.- Title '2Co any Iernaneat equilm,,--nt purchasc-d by funds granted the University sbal.1 be retal.nel by t-be University_in 3-ieu of bigher overhem rates- 8. In t6r@ntttion--.-ith travel xmder this project., It Is agreed th2at the Agency vilY-6d7@the travel documeni-atlon and elr-counting Wl)ic-h conform with the practices of the University. 9. It Is elaritti-that technical reports reflectin4g_tle pro6-ress of the research2 pro&ran a-t--wutually acceptable int4erVe.16. 10. Dr. Pfeiffee has slgr)ed t,be --M,--moraridum of Agreeinent P-nki hol.ds a TUP SECRET Agency Secxirity Approval. T@,-,S/Cbemical Division "PR(,Vr--.D FOR OBLIRATION OF FUrlrG:-- OT Date: Attacb-m, r--n t: Propor,al Distribution: i to: ("C!" Original orlly lY 8'4th ity 00: eate: )e 19 ("TPOPOSED RESEARCH FOR of the potential hallucinatory C cm!- 1. Continued testing program in animals and man . h h*ch become available from e been synthesized by cals which hav 2 w i als awaiting testing in man. ow h co-m@erc.tal laboratories. as 30 chemic I in preliminary trials modifies the LSO-25 model psychosis 2. 2-dimethylautinoethano in that t-he onset of symptoms is delayed but in2 the individual subjects the visual hallucinations are more f,requent. A double blind test of rigid design will bt set up to quantify this effect. The possible occurrence of 2-diwhethylaminoethanol in natural foods will be 4deter- mined by steam distillation and paper'chrconatography. I be ir,)de on darniti!)e and its tertia2ry ainine derivative to ascertain its Tests wil possible role as a neurohumor in-the central nerwous system. 5. The D and L forin@ of lactylcholine have been synthesized and will be extensively tested in animals to ascertain the possible similarity to acetylcholine. Other natural occurring alpha hydroxy acids will be esterified to choline to determine their potency. 0 6. Continued testir@9 in man and animals of those compounds which may be submitted by the Determination of the effect of candidate hallucinogens on d-aminoxidase activity i-n vitro. RNIN(3 s@ ITIVE I E@CE SOURCE lio 1! Oil Department of Phartracology Carl C. Pfeiffer., Ph.D.0 )i-D. PROPOSED BUDGET 1958-1959 personnel- Director, Carl C. Pfeiffer (part7.time) 3,000 o f 2 (f u I 8,000 Asst. Pr ians Atlanta Penitentiary 3,000 2 Ph sic y 3,000 3.,000 Research Ass t - 2 Techniciianp 3,800 2,,500 Graduate St@dent 2,1400 Aninal Attend.y4m=gw ,020 2 Social, Stcurity--and I.A.A.- @T. $29,720. 70TAL PERSONNEL Stipends for human volunteers 3,600 consurrable supplies 52.,Ooo 4,000 Equipment 1,500 Travel $ti3,820 107. UNIVERSITY OVERHEAD 1"3 IOTAL PROPOSED BUDGET @48,202 %C[.r-, 1, Q-r)@T vf:o 19 June 190 VW--,CT Vul,,projoet hlo A4,litlccal AutbvrltaUc4 I;oi 6 t),@a authority 4itod 2 W/A the extlms I co 13 April 1953., flrm XI -tO 0-1 ro cvt-hl of tYAs "thority-in eutso(@ue!nt Ou't'P dit'.0c@at olt's cf 2@,,,opip.o3 t@as atAaorlxe4 to covtr the oul f 450ilroos 'projoztlg e,xpeq"a (thare-C@y t-rin6ina tO 6 tOt 1 4D @0) to 1.0 2 to ki-lotev@@nt Awda (>bliCat@cd d@i@@M kY Chief IM/Cboaical Division MI OBLIGkTlCtf -OiP-YWiDS1 3 -E Th. c c tor I)atet & 2 - Adana VI 2 - r_l s D WIORY tor pfetfferg Dr - 0 perio&- C% f 'R c c e 2 00// pecei-iea, ell 1* *,22 695-11- Direct 6)000.00 sorinel p per 409.00 2 3) elyel Tr ppi-ics 3able T,Otai- Direct 1--n-alrect C@OD_T 26h .(a co triwtion to n 2 Tot*-l gxpendaturcs f ce as 0 Dal" u SCY see attache& lyORY @Lpp-,-3o-v e C. Cnie ACC - - iffers cax proseci DIORY UNIV&R31TY CreLut Dr$ Caxl Co F'fel-ffez Dirtttor 2 Position Arount Student-Assista@nt-- ioo.oo Reoe,--@ AssiCtant--@. ReseArc@h Asrletant 2 r Restamb 3,000 00---- Assist,-@nt I..033:32 Toohnici&j2 750-00 ReseArch ia3.00 W.1 Student A"io SW4@nt Assistant J.- 327.00--- 2 @00-00 3,p 5.00 Asst. Pl@ofitt6t-!-@@ V2 Student Aerist--@nt- 2 lc)o. 00 cii&sliato- P-2. @o Triiti.@ittor 45.00 Soci&l Security- 2 Tot&l-rersonnel-- 6@ -5@n 6oo. oo 2 2.,700.00 2 j7cq!--c2 Tote-I Fel-lovshlps 6a2 T. 0"0 7 )Iur@an Subject4i 7 97 rant Dep&rtmeat of FKkirg@ Dr--,rarl C- Pfeiffer, Director- TRAYEL Date InLiAvId)ial Destin--ttloa Ck.1;4j 6/28-30/5-T Dr -C,&rl C;@7Pfeiff.@@@Chict@go. 71.26 8/23-30/57 Dr Carl C.2-Prelff6t77@74 110.96 84-37 9/3-7/57 Dr.@crri 0. r@fei f f6-@Wa&btr%6ton,,]D.C;- 245.61 C-- 9/3-10/57 41883 (4.60 3,;.>/5 - 6/>7 Dr. Cmrl C.-,Pfeiffer---W"hi-rtatoh@;D.C. 46.-flo 103-10 I/ L> 4 - 22,11 iir, Carl c@@imiffor KE4 yoik city & mi6dieti@@6@-coni'. h9471 183.,Io h/li.-Ig/@8 Dr.- Carl. C@71>A-eiSfer chicazo 1 fnd-@ Philp--a,-IpbiA ti42(2 Total Travel FYIORY UNW&RSM o@ C@X C._@feiffe-r,_RI175@,@tDr Amouyf ---- rrm 2 238-39- Tyo Tr7&nsduce-ro., model FT:03 ph SeiAor "e_i it@41170.. 230-85 Precision i 36.0 r,ject-ric Welder 2 399-7 rysiolofical. pressure transducer 26-50 n-ei&lit , pno, IAIXV 4t@ers, reaction Yessels Foreo cable- -corl2yltetoro Gl,ass Yodel,-YT 3.0 243-69 di6@l,a@om.nt trans&ucer Steel.Case 159.os 2qo.16 6 LY@v-riter 551.63 TWIO deskep TWO &airs internal Totsl -EquilcLcnt MPFliDABfA SUTPIJE3 D*RY- V'NIYKR31T'f Dep@xtwat 0 Dr. 2 C-&rl-C@@Ffeiffer Di-re,,-tor A.VIOUNT lTiX A240M ITRX Dogs 2 36.oo Kyr.)er ki.93 -Cbe-mi@lt i7.6i ch @"- CAI detelIL'in,@%tions 3-09 2 C9.91 8-33 Ch-"- ell tape: 5-3 ig.81@@ sc@ot Data sbeets Dsta pads 45.32 Xises lab. tupplies 10.67 n, e rijo--. c t e rs 31,63 l7e37 2 cbe-ilc-&Is Pi 75- chent"ls 22.20 Di-ffusion unit ;i'.96 N"d-les,, valye, sto;.Ooasp ('be-IcaU 2 c@bemicals Y&na&l I 55 Che-MleaU Xica 60:91 ras-W)___ 14-83 Chealea2-le, h4.20 Aniral food. cdd&r rbavings 37-70 Catg,p postage 39-48-pho-tosiar4ic vork cheticau 246-83-- - t@e-aca-l-deterA-a-,tions 40.60 Cult,ire h-47 )4io6t lab. supnlies 38.84 Chemica-15 3-31-- 2 Reference lr.-ok 3.83 Alcobol 6*41 R@pailr rostoid roagmers -,5.0 Cbet-dlcale 2 food: 2,5-627 Spatalos, ebemicals 3h*56 Che@@dcAls-- - 54 .79 Cats,, lab. supe.-lies l@. (10- PIYVO04 2 7.81 C,atep lab. 3 -46 Re&iaator 30-13 r,ottles, tubing adapter 4 I -9 57 --- Ini erro--, @e t-e r-a. 61-43 Anir-alL fOO4 42.i6 itepr:Lnts @9.65 Che-aleaU 5.83 Alcohol 2.56 AnJ-rAl 2 food 4 - eu c @.80 3-78 Fbarr^c ti &I $uPP'4e$ Cbemice,'La 19.37 Ch e@@2A c et-ls - ---@ 47.84 ,Anir.,,,%l food 13-39 Refer,@nct bOOkp slides ih.io - -beatc 2 90 Cats )4.oo --- -C -&Is 2 c-be.,niml 41.00- Thei-m-@CCtersi, ebemicals 13:.- 2 FrelE@it h.n Office supplies 10.00 C'h"- 19' 57 ----Table ea-rt 67-35 li-lub c 2 A.ICO%01 3-85 Reseer-<,-'n notel.K@o%s - 58-55 Recoi-4 suppiles 29-025 2 CbeAtcals 8.47 Yeltil@g point O.Pi---mtus ?l 73 71-- 1.ePrJ-nt-2 31.63 Wire, t-ubi-" lg:n R26duction se,;kr 10.25 Cat,s,, post@Rze., ase. supp !it-9-38-91- Cbe---icalf 2-93- Phlex-.:sce,itic&l suppl-i" 2 24.@O neifht 4-23 Cb".-ic.a-'L crialyst4 6.65 Yice 33-h3' Pipett,cas acetone- -11,&rolue 2 84.91 21.80 st(tl-mlcsa Steel clatulas 2@4.00 53Ades 7-93 C'@-e-z@Icals 2 155-50 ilork Liycr- h.go .knirzl food 26.27 st..trditils 1.22 X t)i e-r 17 - 31---C2hedc-&Ia., tubing,, a tcrp,--,-rs @7668 @otographic ne'rylea .10 f i a r 02 Cr-,ntinUO4 next wlitr@n 1 C@onttnue4 to PeZe 2 -EW4NDABLE SUPPIJrsS ITFX AYIOUNT I AMOUNT Forv&rl fr@om Page I.- Dzvza 3-5.97 Alutr@Likim foil,# d-isponser 18.94 Ylectric Yotor 8.76 12.57 - 84 Bottles Rise. IA'O. supplies 37. 31-93 2 19-60 Ya&netic bar&: 3-99 Apr<>n., f3af@is., Plastic & 35-82 ---cover Ec-d berrJn,@t@ne tqve-linv 2 Watch@ glasses@, ebWcaU -A 9-27 St-ethoscope-head; tubing 13 39-@@-St.OPP-'rs 4.27 Cheinic,-.l det.(@,rainations 13:00 2 i6.o7 Svivel c@p-sters 9.02@@- riiil"joati-c pressure regulator 23t68 36.98 Plastic covers.. cbemi"'L* 13.h4 Che-mic-&Is 17.012 Photo&raphic wrk 56 rce torge .11 21 Cbeidc-als 5. 26. 5 Ether., funnels 2 ii.o6 --Reprints Yrei&'ht 36-07 Office supplies Reprints 41-h3 Ch e@--ti -C-0.11-- 8.(o Tape --l. 80 Alcohol n..P,r--.,AceuticeA supplies 8 w- 10.00 CbeiLicals lo-.67 n2, otot-xaphic service 0 Stop2^-rs., greasei test-tlabee-19-003 l@:163 ik&pter 3,PO 1-'L. 25 Che--dcals 22.@8 cbe-A CAI s 2C,6 Cast,ere 6.15. Anir--,l food 44.70 6.56 4 - 9 9.21 fo6d 2 BinAA-ng JOUTOKIS 30-90---- Reference Book 6.51 CheLnic-als 2.- 1 - - - - OL> TotAl Forceps 2 17 Che-.nic-ala 1h.20 Reprints 33-007--l Yisc. lAb. sapplies Cb i I -i 20.8x Freight 2-30 cheffacau 8.55 ""5 Cherical-a , -03 Polyak N-exAp-brate visual ryrte-it 37-@2 Che:@@lc4a de.-tinairations 2 13.39 Yrei&'nt 2.24 Chez,lcels 8.78 5.(Q Eel-lum, Yalve -18.47 )4iecellAneout su:ppll8ej 30-94 Cbt-rlcals i6. 3 3- 3 21.16 Che-Acal dp-tervd-rL%ticng 39-@O RECFIPT of the following two checks, I hereby acknowledge receipt 0. piil 30, 1958, drawn 04 @P,4 dated A Cashier's Check N, ount 2 ? 2., in the. am 'f he %~O" of $3Z. z8o. 6 Registered Check NO. q -Mliltdrawn on tbevgrs" .Z3, in the an-iount of $1 ?,91, D5ate: