t7i Now D A@lloulTr n@CLen'ED FOR G&W $2@750.00 I# 200, 00 C- 100.00 Con-su2lta-tion Dr. Telcrj',ione anli So Tra,tal-Dr. 118-30 Constatnt 232.50 Phomicals v 143.46 Anderson Glass Cp-psule 2 ---(,5,-50- Magnetic Stirring Apparatus -37.50 Kodak Ti-.r@er, Ho@4 Plate --- 29.50 acrew Sta-,id 97.72 Respire.ion Piurt-? 2267.11- Thermometer k- Time Marker triple 102047: Anlr.,als and Supplies 306,16: Unoxl)@6nded Balance- iii- Fund $ 8.45 or 0 ecl to:! r t'114 RECFIPT -I he-roby ackiowledge receipt of the following check: Trc-,asurtris C'@ecl-. No. l/f2433. dat,@(I Atril 11 in r, 00 cira h,- ani::,ii8nt illail@@2@ o th#JN payable Date- 4L) r--i --$ o 0 AD C) 8 4t, C) O i@ c; C,7 116: aA PV c,-m I-Oa P-2Iiii@qu '4T CIDTVJ 1, A -I I:-- E 1 MINI' to (,II U-@ 'J - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ----- to 55, otory, with of 9 -t- I-6 Jo t-liat this etzlly- riol to tl'ii of Ly al,@iorlty o 74'i5 juri-3 CL BY 21 1956 Fat: TIE T@ECO'i-,,D sul3jlr:,@"Ir Pro'eat 1-7@-ULiRA, Subpro',oat 55 1. Subprojr,,c'u 55-i@f@belfig@iiiititLt@@dAb@@enabl(, Dr. OT' S c P -,Co' a d2iqs int ko- uri,:'i.!@r' Dep-ar' ,ae t f 2. The scopa of the project thi relatio?iship betwnen cheiaical struotLr(,-,-Aiid biolo-cical activity of var,-'Lous iso- 2 y quinolinc@ d;!r-'Lvatives a@ict he@terocyclic compcrandz co-itaiiiinc., two or more ring syst@@ms. Thn ool and Dr.conow@ir,, 2co-,.,)Iete-"Ly urtwittln.,, of A-e,,noy in is-pr..-),-Vosc-,rl-progran. Therefo L 0 - re, !n order to waintain cover, 2 La) the r@,qtiirc-,nppt for-a-l,,'e,-qorarLclL-.q of with the- pri..-iciple investigator-wi-11 be waiv4-,d, (b) th(% will request Di@, to obtain oji 2 acco,an ino-L'ron U-.-iive-raity upon co.-.ip e. on of th@@4ro-@@ e@ year.- ,an The cost of this progrzlm for a p@,r'Lod of on.-,@ yAar-is-ps2ti@@-- inated to b,, T-o-tliia-suii-must bt@ tddod '108.00 r,--presf@nt- in@'y a foitr ppreont sprv!cA-c',Iargp by the th-rpf Ore. 2 will not exde@@,d -na q tha total cos 00 a atiould b,,@ a--ainst Allot.--opnt 6-2502-10-.30lt 5. Title to "y peimanpnt equiprinitt varchis2ed by L'ut-ids @-rant@-,d th,i@ Uqivorsity shal,l-',-,e by thp Uni.ve s r ity in lipu of overhpad rat,!@si to. ,)..I t 117 1: T to o@2 137"i5 19'77 By 187473 c 0. Doctir-n-nt,,ition %a-,ou-,itin-, for trave@l (,.xoArsps which or^ roinbirsabip ky tho Utiivorsity ahill conform with tliq acqep-tpd practieps of ti'i,'It institution. 2 C@OTTLII,'3 ical Divis4o,,i APPi-trjlr,,D - 2 4@-.rch Dir@@,etor Res,, Distri,btit!Lon: Ori@gi,nal Cnl,y - TSS/CD ------- - -- 6 TSSIC-D FAbruary 1956) Do'@vii@_pr.ided t6 ity 1977 I ti. P D P. T C L Ft Y 1,4 7 4 7,9 00 January 26, 1956 The unrlei-sir,,ned Ayotild grant beginrtirg----- Februai-y 1, 1,056 foi- -12 (@ ',I 2 8,, erc I, ",,o @,,,.Arrie out The purpose o t s is-to-discove.r the 6!inrr.--oblogical. effects of certain pro@,ips Of' co@- by Dre 5i @ pfopaivd I n associa+.-es of the ',2Ibpartrqent c In other woi,@397-vz- tal@e--a-furthei, step into the i=t ba-s c a -)e of pharl-l'ic."016ey--biochepioroholoeyj or the relation of cheaiical structu.ie-and-physic,-11-pivoei-ties-of ne-,r co.,npouri<3-s 2to bi-Dlorical activit:@@@proposo to test the following-co-n-@@--------@l--'@'- pounds: a. Various s.,i-nthetic isoqtiinoline derivatives* be Ifeterocyclic coripourtds--containing-tue@--o moi-@,b ring systeins. It is highly desirabl2e to nectimillate-portinent data on all these types of neii conpov.@,ds for the-treatment-of-disease as well as foi--the--- advance,7@ient of sci-ence itself,, These co--i,:)@Nunds will be tested on the: a. Central nei-ious be Autonot-aic i)eiyous systeiii*- co Sensory nenress de Seiisory nerve ends, e., Soqiatic iiotor nev..ron(,,so This I-las,-,ifi.ca'L-lion, of course, iricludes dnir@s such as those producino. ha-lliicinttionc, tranoiiil.iz@-.tion, sedation, cinestl-iesip-., adi-erei-Lic @;.xid chcli.nergi-c effects, and general in(i locel analL..-esia. In addition, the compounds i;ill be tested a,,3 to their effect on the siiiootti lituscle itself and on possibl-o ant.@,conisrii to bista8.,a,'-re. 2 I iopose that the follo-ging budget be provided for the project: p 275 - Overhead for the University 13700 - Oalax-ies u 250- - Travel and ,A(lirdnistration - Animals, cliei-iicals, and miscellaneous equip,.iptit 525 'MTAL I add th--Lt this gr,) t ']I be a-further step n the n b% e r.-epa,-tf@ients 0 he @itieeii t at t Doctors and.@,JM will be peri6di6ally infor.,-iod as-to the Pospectfully-,eubTitt- L St",N@,ITIVri ICE@ICE